Nonerosive reflux disease
Conditions
Interventions
Control group:placebo
Treatment group:Tongjiang granules
Sponsors
Wuhan No.1 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Meet NERD Western medical diagnostic criteria; 2) Patients with poor treatment effect of antacids; 3) Be between the ages of 18-70 years; 4) Meet the diagnostic criteria of TCM hepatic and gastric depression syndrome; 5) The patient has informed consent and is willing to accept the corresponding treatment.
Exclusion criteria
Exclusion criteria: 1) Patients with active peptic ulcer gastrointestinal bleeding severe dysplasia of the gastric mucosa or suspected malignant transformation patients with bradycardia or postoperative patients with cardia failure; 2) Have other organic diseases of the digestive system (such as acute and chronic pancreatitis liver cirrhosis etc.) or systemic diseases that affect the motility of the digestive tract (such as: hyperthyroidism diabetes chronic renal insufficiency psychiatric and nervous system lesions etc.); 3) Patients with serious lesions of major organs such as heart liver and kidney hematopoietic system diseases and tumors; 4) Pregnant and lactating women; 5) History of neurological and psychiatric diseases; 6) Those who have a history of allergy to the drugs used; 7) Subjects who are participating in other clinical trials or within 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acid reflux,heartburn symptom score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-rating scale for anxiety and depression;TCM syndrome score;GERD-HRQL;Secondary symptom score(chest pain;upper abdominal pain etc);Chronic gastrointestinal disease PR0 scale; | — |
Countries
China
Contacts
Public ContactShi Zhaohong
Wuhan No.1 Hospital
Outcome results
None listed