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Exploring Local Microenvironmental Changes in Acupoint Sensitization Among Chronic Atrophic Gastritis Patients Using Proteomics and Metabolomics

Exploring Local Microenvironmental Changes in Acupoint Sensitization Among Chronic Atrophic Gastritis Patients Using Proteomics and Metabolomics

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025000156
Enrollment
Unknown
Registered
2025-01-20
Start date
2025-01-20
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic atrophic gastritis

Interventions

Chronic atrophic gastritis group (tissue fluid sampling in CV12 and non-point areas):none

Sponsors

School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1)The patients diagnostic report within 6 months meets the diagnostic criteria for chronic atrophic gastritis and is consistent with OLGA staging system stages III-IV and OLGIM staging system stages 0-V. (2)Between 40 and 65 years of age regardless of gender. (3)Difference between CV12 and non-acupoint pressure pain domains greater than 10N. (4)Patients had good compliance volunteered to participate in the study and signed an informed consent form.

Exclusion criteria

Exclusion criteria: (1)Combined autoimmune gastritis (type A chronic atrophic gastritis) peptic ulcer gastric ulcer duodenal ulcer special type of gastritis or gastrointestinal bleeding; (2)Those whose gastroscopy and pathological biopsy have shown cancer or whose imaging tests suggest cancer metastasis; (3)Those who are taking pain relieving drugs and hormone drugs; (4)Patients with unclear consciousness inability to express subjective symptoms of discomfort and psychiatric patients; (5)Suffering from serious cardiovascular cerebrovascular hepatic renal hematopoietic system diseases malignant tumors and other serious life-threatening diseases; (6)People with scarred body local scarring or injury at the detection points skin diseases and peripheral nervous system diseases; (7)Subjects with diseases that cause abnormal basal body temperature such as metabolic disorders like abnormal thyroid function; (8)Those who have had gastric surgery or have had major surgery resulting in defects or changes in vital organs; (9)Pregnant or lactating women; (10) Those who have undergone acupuncture or participated in other clinical trials within the last six months

Design outcomes

Primary

MeasureTime frame
Differential metabolite concentration;Differential protein concentrations;

Secondary

MeasureTime frame
Metabolomics of tissue fluid;Gastroscopy and pathological biopsy;Gastrointestinal Symptoms Rating Scale;Updated Sydney System;pressure-pain threshold;Proteomics of tissue fluid;

Countries

China

Contacts

Public ContactCunzhi Liu

School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine

lcz_tg@126.com+86 15901261692

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026