Recurrent herpes simplex virus keratitis
Conditions
Interventions
Experimental group:Qijin Tuyi Granule combined with ganciclovir eye gel. If there is epithelial defect during treatment, befusor eye drops or befusor gel can be added to the eyes, 2-6 times a day (dep
Control group:Qijin Tuyi Granule simulator combined with ganciclovir eye gel. If there are epithelial defects during treatment, befusor eye drops or befusor gel can be added to the eyes, 2-6 times a d
Sponsors
Eye Hospital China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.At least one eye meets the above western medicine diagnostic criteria and Chinese medicine syndrome diagnosis criteria; 2.Age 18-65 years old (male or female); 3.At least one recurrence and can provide evidence (such as cases diagnostic data prescriptions etc.); 4.Eyelid tissue does not interfere with corneal examination; 5. The subjects can understand and are willing to receive treatment and review according to the experimental protocol; 6. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. People who are allergic or allergic to known drug ingredients; 2. Patients with other ocular diseases (excluding drug-induced keratopathy other infectious and allergic keratopathy) or systemic diseases (such as corneal diseases other than HSK glaucoma retinal diseases uveitis optic neuritis diabetes with poor glycemic control (hemoglobin Aglycated =9%) systemic infections) that the investigator determined interfered with the evaluation of the efficacy of the investigational drug; 3. Moderate or severe liver dysfunction or serious heart lung renal dysfunction hematopoietic system diseases and psychiatric patients; 4.Patients with a history of malignant tumor within 5 years; 5. Unable to cooperate or unwilling to cooperate due to mental illness; 6. Persons with disabilities defined by law (blind deaf mute mentally handicapped etc.); 7. Suspected history of alcohol drug or drug abuse; 8. Pregnant or lactating women; 9. Women of childbearing age or subjects whose menopause is less than 12 months must undergo a blood/urine pregnancy test during the screening period and the result must be negative; 10. Patients who have participated in clinical trials of other drugs within the last 3 months; 11. The investigator considers it inappropriate to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HSK recurrence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Eye symptoms (photophobia, tears and pain, bloodshot eyes);TCM syndrome score;best corrected visual acuity;Corneal condition (slit-lamp examination, corneal fluorescence staining examination, photographic examination of anterior segment);Recurrence situation (recurrence number, recurrence interval); | — |
Countries
China
Contacts
Public ContactZefeng Kang
Eye Hospital China Academy of Chinese Medical Sciences
Outcome results
None listed