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Mechanism of electroacupuncture regulation of CCL2/CCR2 pathway in relieving neuropathic pain

Mechanism of electroacupuncture regulation of CCL2/CCR2 pathway in relieving neuropathic pain

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025000134
Enrollment
Unknown
Registered
2025-01-16
Start date
2025-02-05
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Secondary sciatica due to lumbar disc herniation

Interventions

Electroacupuncture combined with nerve block group: Electroacupuncture combined with nerve block group: on the basis of lumbar nerve root block, combined with electroacupuncture treatment.
Electroacupuncture group:Before needling, use a 75% alcohol swab to disinfect the local skin of the acupoint, and fix a sterile sponge pad to the skin of the local acupoint area. Apply electroacupunct
Neuroblock group:The patient selects a suitable position, selects the puncture site, and after routine skin disinfection, local anesthesia is first administered. Then, a puncture needle is inserted, a

Sponsors

Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Individuals aged between 18 and 60 (including both 18 and 60 years old) regardless of gender. (2) Meets the diagnostic criteria for secondary sciatica caused by lumbar disc herniation. (3) Agree to comply with the research protocol and complete the study as required by the protocol. (4) Can cooperate with examination and treatment understand and cooperate in filling out survey questionnaires and scales sign informed consent forms and voluntarily participate in this study. Only those who meet all four criteria can be included in the experiment.

Exclusion criteria

Exclusion criteria: (1) Severe progressive neurological symptoms (such as cauda equina syndrome and progressive muscle weakness); (2) Individuals with a history of lumbar spine surgery; (3) Excluding lower limb pain and other symptoms caused by lumbar spine reasons such as dry sciatica; (4) Central type protrusion with radiating pain symptoms in both lower limbs; (5) Patients with severe heart and lung diseases; (6) Pregnant or breastfeeding women;

Design outcomes

Primary

MeasureTime frame
The average decrease in NRS score for leg pain in the fourth week compared to baseline;

Secondary

MeasureTime frame
Other evaluation time leg pain numerical simulation score NRS decreased compared to baseline;Concentration of IL-1 ß in serum before and after treatment;Concentration of CCL2 in serum before and after treatment;Concentration of CCR2 in serum before and after treatment;The number and proportion of CX3CR1+immune cells in serum before and after treatment;Concentration of IL-10 in serum before and after treatment;Concentration of IL-4 in serum before and after treatment;Decreased value of NRS in low back pain digital simulation score compared to baseline;The number and proportion of CCR2+immune cells in serum before and after treatment;Concentration of IL-6 in serum before and after treatment;Oswestry Disability Index;

Countries

Chinese

Contacts

Public ContactLiu Guokai

Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital

guokai_liu@126.com+86 186 1085 1898

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026