Secondary sciatica due to lumbar disc herniation
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Individuals aged between 18 and 60 (including both 18 and 60 years old) regardless of gender. (2) Meets the diagnostic criteria for secondary sciatica caused by lumbar disc herniation. (3) Agree to comply with the research protocol and complete the study as required by the protocol. (4) Can cooperate with examination and treatment understand and cooperate in filling out survey questionnaires and scales sign informed consent forms and voluntarily participate in this study. Only those who meet all four criteria can be included in the experiment.
Exclusion criteria
Exclusion criteria: (1) Severe progressive neurological symptoms (such as cauda equina syndrome and progressive muscle weakness); (2) Individuals with a history of lumbar spine surgery; (3) Excluding lower limb pain and other symptoms caused by lumbar spine reasons such as dry sciatica; (4) Central type protrusion with radiating pain symptoms in both lower limbs; (5) Patients with severe heart and lung diseases; (6) Pregnant or breastfeeding women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average decrease in NRS score for leg pain in the fourth week compared to baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other evaluation time leg pain numerical simulation score NRS decreased compared to baseline;Concentration of IL-1 ß in serum before and after treatment;Concentration of CCL2 in serum before and after treatment;Concentration of CCR2 in serum before and after treatment;The number and proportion of CX3CR1+immune cells in serum before and after treatment;Concentration of IL-10 in serum before and after treatment;Concentration of IL-4 in serum before and after treatment;Decreased value of NRS in low back pain digital simulation score compared to baseline;The number and proportion of CCR2+immune cells in serum before and after treatment;Concentration of IL-6 in serum before and after treatment;Oswestry Disability Index; | — |
Countries
Chinese
Contacts
Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital