Refractory gastroesophageal reflux disease
Conditions
Interventions
Treatment group:Shugan Hewei Formula were taken orally one dose a day 2 bags in total 1 bag each time 1 hour in the morning and evening after meals for 8 weeks
Placebo control group:Shugan Hewei Formula with 10% content were taken orally one dose a day 2 bags in total 1 bag each time 1 hour in the morning and evening after meals for 8 weeks
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the Western diagnostic criteria for refractory gastroesophageal reflux disease; 2. It meets the diagnostic criteria of TCM syndrome of liver and stomach disharmony; 3. Age =18 and =80 years old gender is not limited; 4. Voluntarily participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe gastrointestinal diseases: peptic ulcer history of gastroesophageal and duodenal surgery Zhuoyi syndrome primary esophageal motility gastrointestinal malignancy etc.; 2. Serious primary diseases of heart-brain liver lung kidney blood endocrine and other important systems; 3. Persons with severe mental illness; 4. Those who cannot take medicine during pregnancy pregnancy or lactation; 5. Allergic to the drugs used in this study; 6. Participants who took the same drug treatment regimen as the study before enrollment; 7. People participating in or within 4 weeks of clinical trials of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Esophageal Hypervigilance and Anxiety Scale-7;Patient Health Questionnaire-9;Visceral Sensitivity Index;?-Aminobutyric Acid;TCM syndrome score scale;glutamine;glutamate; | — |
Countries
CHINA
Contacts
Public ContactFANG Shengquan
Yueyang Hospital of Integrative Medicine Shanghai University of Traditional Chinese Medicine
Outcome results
None listed