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The effect of Bai Tou Weng Tang combined with chemotherapy on gut microbiota and lipid metabolism in patients with damp heat type colorectal cancer

The effect of Bai Tou Weng Tang combined with chemotherapy on gut microbiota and lipid metabolism in patients with damp heat type colorectal cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025000110
Enrollment
Unknown
Registered
2025-01-14
Start date
2023-11-01
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Baitouweng Tang combined with chemotherapy group:The combination of traditional Chinese medicine and chemotherapy group received oral administration of Bai Tou Weng Tang in addition to the chemotherap
Simple chemotherapy group:Modified FOLFOX regimen or Capecitabine and Oxaliplatin regimen

Sponsors

Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) Postoperative patients with damp heat accumulation type CRC who meet the criteria of stage II-III and have not undergone chemotherapy or radiation therapy before surgery; 2) The range of body mass index (BMI) is 18.5kg/m2 = BMI < 24kg/m2. 3) The hospitalization case information is relatively complete and complete; 4) Expected survival period exceeds 1 year; 5) Patients who conform to the dialectical treatment of traditional Chinese medicine and belong to the type of dampness heat accumulation.

Exclusion criteria

Exclusion criteria: 1) Possible factors that may affect serum lipid levels: familial hyperlipidemia individuals with a history of secondary hyperlipidemia (thyroid gland)Dysfunction obesity diabetes nephrotic syndrome hormone and other drugs taking history) use of drugs affecting blood lipid metabolism in the past two weeks Substances (heparin statins etc.); 2) Patients with severe primary diseases such as liver kidney and hematopoietic system as well as psychiatric disorders; 3) KPS score less than 70 points; 4) Prior to admission chemotherapy radiation therapy and other treatments have been performed in an external hospital; 5) Individuals with a history of malignant tumors in other areas;

Design outcomes

Primary

MeasureTime frame
Intestinal flora testing;Isopretenol lipids;Glycerophospholipids;Fatty acyls;Sterol lipids;Glycerides;Sphingolipids;—

Secondary

MeasureTime frame
Traditional Chinese Medicine Syndrome Score;Immune function (T lymphocyte subsets);KPS score;Tumor markers;—

Countries

China

Contacts

Public ContactWeidong Chen

Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University

weidongchen_doctor@163.com+86 187 8308 1863

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026