Parkinson's Disease
Conditions
Interventions
Acupuncture intervention group:acupuncture at Siguan Point
Sham acupoint acupuncture group:Acupuncture at non-chnnal-non-acupoint
Acupuncture group:Acupuncture at the Siguan point is administered to Parkinson's disease patients undergoing deep brain electrical stimulation surgery
Control group:No acupuncture and moxibustion intervention for Parkinson's disease patients undergoing deep brain stimulation surgery
Sponsors
Tsinghua University Yuquan Hospital(Tsinghua University Integrated Traditional Chinese and Western Medicine Hospital)
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for Parkinson's disease patients: a. Patients aged 45-75 with primary Parkinson's disease; b. The course of Parkinson's disease is 5 years or more; c. Hoehn Yahr (H-Y) stage is 2.5 or above in the "closed" state (not taking medication); d. UPDRS motion score = 30 in the "off" state; e. Good response to dopamine drugs, with an UPDRS motor score improvement rate of over 30% in acute levodopa experiments (experimental drug Madopar 250mg); f. Those who have a daily medication cut-off period of at least 6 hours, or experience serious movement complications such as abnormal movements, or who repeatedly adjust medication but still cannot effectively improve; g. Mini Mental State Examination (MMSE) score = 24 points; h. No contraindications for magnetic resonance imaging testing. 2. Inclusion criteria for healthy subjects: a. Age range of 45-75 years old, confirmed by health examination to have no organic or significant functional diseases; b. No family history of mental or neurological disorders; c. There were no physical abnormalities (such as headache, fever, cough, etc.) at the time of enrollment; d. Not taking excitatory drugs; e. No contraindications for magnetic resonance imaging testing.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for Parkinson's disease patients: a. I have undergone surgical treatments for Parkinson's disease other than deep brain electrical stimulation, such as stereotactic destruction, cell transplantation, gamma knife, etc; b. The 'closed' state has serious midline symptoms such as language disorders, swallowing difficulties, and balance disorders; c. There are contraindications for neurosurgery, such as cerebral infarction, hydrocephalus, cerebral atrophy, ventricular enlargement, sequelae of cerebrovascular disease, as well as cardiovascular and cerebrovascular diseases such as heart disease and severe thrombocytopenia; d. There are other accompanying diseases that require or have been implanted with pacemakers, defibrillators, cochlear implants, and other nerve stimulators; e. There are accompanying diseases that seriously affect health, such as tumors and severe abnormalities in liver and kidney function (indicators exceeding three times the normal value). 2. Exclusion criteria for healthy subjects: a. Breastfeeding, pregnancy, and menstrual women; b. Physical abnormalities (such as headache, fever, cough, etc.) occurred during the trial period; c. Unable to cooperate with the completion of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium incidence rate;CAM-ICU( Confusion Assessment Method-ICU);CAM(Confusion Assessment Method); | — |
Secondary
| Measure | Time frame |
|---|---|
| rSO2(cerebral oxygen saturation);PSQI(Pittsburgh Sleep Quality Index);BIS(bispectral index);MDS-UPDRS-I(movement disorder society-sponsored revision of the unified Parkinson's disease rating scale-I);MDAS(Memorial Delirium Assessment Scale); | — |
Countries
China
Contacts
Public ContactMA Yu
Tsinghua University Yuquan Hospital(Tsinghua University Integrated Traditional Chinese and Western Medicine Hospital)
Outcome results
None listed