Mild cognitive impairment due to Alzheimer's disease
Conditions
Interventions
Control group:Basic treatment + Shenghui decoction placebo
Treatment group:Basic treatment + Shenghui decoction granules
Sponsors
The First Affiliated Hospital of Henan University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age 55-80 years old (including 55 and 80 years old) gender is not limited; (2) meet the diagnostic criteria of MCI Western medicine; (3) Cranial MRI showed atrophy of the hippocampus entorhinal cortex and other parts; (4) Meet the TCM syndrome type diagnostic criteria for MCI with heart and kidney deficiency; (5) 18 points= MoCA scale score<26 points; (6) Hachinski Ischemia Scale (HIS) score= 4 points; (7) Hamilton Depression Rating Scale (HAMD-17 items) score = 24 points; (8) Have the ability to read write and communicate at the time of screening and be able to cooperate with the completion of the neuropsychological assessment specified in the program; (9) Have a stable caregiver who can accompany the subject to the study visit. (10) The subject voluntarily participates in the clinical trial and signs the informed consent form. Those who meet the above conditions at the same time can be selected.
Exclusion criteria
Exclusion criteria: (1) Dementia caused by any cause other than AD including but not limited to: (1) Subjects suffering from other organic diseases such as: vascular dementia Huntington's disease Parkinson's disease frontotemporal dementia Creutzfeldt-Jakob disease amyotrophic lateral sclerosis dementia with Lewy bodies subdural hematoma hydrocephalus cerebral contusion cerebral malacia central nervous system infection (syphilis AIDS encephalitis meningitis) neuromyelitis optica intracranial space-occupying lesions (subdural hematoma brain tumor etc.); (2) Have suffered from major physical diseases in the past such as: hepatic encephalopathy pulmonary encephalopathy dialysis encephalopathy hypoxic encephalopathy etc.; (3) Dementia caused by other physical and chemical factors such as drug poisoning alcohol poisoning carbon monoxide poisoning etc.; (4) As judged by the investigator the subject suffers from mental illness such as major depression (Hamilton Depression Rating Scale score = 25 points) epilepsy schizophrenia etc.; (5)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADAS-cog; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;TCM Syndrome Scale;Activities of Daily Living Scale;Mini-Mental State Examination;Digital Breadth Test; | — |
Countries
China
Contacts
Public ContactZhangJie
The First Affiliated Hospital of Henan University of Chinese Medicine
Outcome results
None listed