Knee osteoarthritis(KOA)
Conditions
Interventions
Observation group:Basic treatment + conventional western medicine treatment + traditional Chinese medicine encapsulated treatment
Experimental group:Basic treatment + conventional western medicine treatment + external coating treatment of traditional Chinese medicine formula granules
Control group:Basic treatment + conventional western medicine treatment
Sponsors
Guangdong Second Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 55-80 years with unilateral KOA were treated with TKA; 2. Meet the diagnostic standards and TCM diagnostic standards; 3. The X-ray condition meets the above grading criteria; 4. No mental abnormality able to communicate accurately; 5. Those who have not been treated or taken other drugs in other ways in the past half month; 6. BMI value less than 28; 7. Those who are willing to test have good compliance and agree to participate in this pilot study.
Exclusion criteria
Exclusion criteria: 1. Patients who do not meet the inclusion criteria; 2. Non-primary KOA such as gouty arthritis hemophilic arthritis etc.; 3. Severe valgus deformity of the knee joint (deformity angle >15°) with (or) rigidity (knee range of motion <90°) or with severe bone defect; 4. Combined with important system dysfunction severe cardiovascular and cerebrovascular chronic diseases; 5. Patients who are not suitable for surgery such as skin breakage ulceration local infection etc.; 6. Knee surgery in the past 6 months; 7. Patients with other diseases accompanied by lower limb pain such as lumbar intervertebral disc herniation and lumbar spinal stenosis; 8. Engaged in professional sports or manual labor industry; 9. Have a history of vascular lesions of the lower limbs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quadriceps VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| HSS score of the knee joint;The degree of swelling in the thighs;Oxygen radical marker MDA;Oxygen radical marker SOD;Serum inflammatory marker IL-6;Serum inflammatory marker TNF-a;Area of subcutaneous ecchymosis; | — |
Countries
China
Contacts
Public ContactZhao Chuanxi
Guangdong Second Hospital of Traditional Chinese Medicine
Outcome results
None listed