Skip to content

The effects of exercise on gut microbiota in older people with sarcopenia: a study protocol for a randomized controlled trial

A study on the clinical effects of Baduanjin combined with resistance exercise on older adults with sarcopenia in Chinese community

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025000036
Enrollment
Unknown
Registered
2025-01-07
Start date
2025-01-13
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sarcopenia

Interventions

control group:Health education, 60 minutes each time, once a month for 12 weeks
Baduanjin Combined Resistance Exercise Group:Baduanjin combined with resistance exercise 45 min each time three times a week for 12 weeks

Sponsors

Chongming Hospital Affiliated to Shanghai Health Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1)Individuals aged = 60 years. (2)Individuals diagnosed with sarcopenia according to the Asian Working Group for Sarcopenia 2019 criteria (AWGS 2019): 1)Appendicular skeletal muscle mass index (ASMI) measured using bioelectrical impedance analysis (BIA) is < 7.0 kg/ m2 for men and < 5.7 kg/m2 for women; and 2)Handgrip strength (HGS) is < 28 kg for men and < 18 kg for women; and/ or 3)6-m gait speed (GS) is < 1 m/s. (3)Individuals without regular exercise habits (regular exercise is defined as engaging in = 20 minutes of vigorous physical activity on =3 days per week or = 30 minutes of moderate-intensity physical activity on =5 days per week). (4)Individuals who participated voluntarily and provided a signed informed consent form.

Exclusion criteria

Exclusion criteria: (1) Individuals with absolute contraindications to exercise such as deep vein thrombosis or coagulation disorders. (2) Individuals with cognitive or sensory impairments that prevent effective communication with the researcher. (3) Individuals with medical conditions that interfere with their ability to complete assessments or interventions including musculoskeletal disorders (e.g. fractures) cardiovascular disorders (e.g. uncontrolled hypertension dyslipidemia history of malignancy stroke acute myocardial infarction angina pectoris ventricular tachycardia) cerebral infarctions malignancies or disabilities. (4) Those with infectious skin diseases or unhealed or ulcerated wounds. (5) Persons who have regularly taken the following drugs in the past 3 months: antiplatelet drugs (e.g. aspirin Aggrenox ticlopidine etipaterol and tirofiban) analgesics anticoagulants antihypertensives or lipid-lowering drugs. (6) Individuals who have received interventions that may affect the gut microbiota (e.g. antibiotics or probiotics) or have a history of inflammatory bowel disease gastrointestinal surgery or cancer within 1 month prior to the collection of the faecal sample.

Design outcomes

Primary

MeasureTime frame
Changes in the gut microbiota;Knee extension strength;

Secondary

MeasureTime frame
Nutritional status;Physical performance;Physical activity;Muscle mass;Handgrip strength;

Countries

China

Contacts

Public ContactChen Nan

Chongming Hospital Affiliated to Shanghai Health Medical College

chennanreha@126.com+86 181 0184 3311

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026