lower extremity arteriosclerosis obliterans
Conditions
Interventions
Critical limb ischemia:Observational study
normal lower extremity vascular:Observational study
Arteriosclerotic obliterans:Observational study
Sponsors
Beijing University of Chinese Medicine Third Affiliated Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients without lower extremity vascular sclerosis : 1 age > 40 years old ; 2 no smoking diabetes hypertension hyperlipidemia and other high-risk factors ; 3 patients who voluntarily accepted and cooperated with the examination and agreed to participate in the clinical trial. Early stage of lower extremity sclerosing occlusive disease : 1 Age > 40 years old ; 2 smoking diabetes hypertension hyperlipidemia and other high-risk factors ; 3 patients had clinical manifestations of lower limb ASO such as intermittent claudication rest pain lower limb nutritional disorders etc. 4 The distal arterial pulsation of ischemic limbs was weakened or disappeared ; 5 ABI = 0.9 ; ( 6 ) Color Doppler ultrasound CTA MRA DSA and other imaging examinations showed stenosis or occlusion of the corresponding arteries. Late stage of lower extremity sclerosing occlusive disease : 1 Age > 40 years old ; 2 smoking diabetes hypertension hyperlipidemia and other high-risk factors ; 3 Rest pain of lower limbs lasted for more than 2 weeks ; 4 lower extremity ulcers gangrene ; ankle systolic blood pressure < 50mmHg or toe systolic blood pressure < 30mmHg.
Exclusion criteria
Exclusion criteria: Patients without lower extremity vascular sclerosis : 1 patients who participated in other clinical trials in the past 2 months ; 2 pregnant and lactating women ; patients with recent myocardial infarction ; 4 moderate to severe cranial artery stenosis Takayasu 's arteritis or carotid artery embolism ; 5 severe heart lung or renal insufficiency ; 6 intracranial hemorrhage occurred in the past 1 year ; 7 Patients with malignant tumor. Early stage of lower extremity sclerosing occlusive disease : 1 patients who participated in other clinical trials in the past 2 months ; 2 pregnant and lactating women ; patients with recent myocardial infarction ; 4 moderate to severe cranial artery stenosis Takayasu 's arteritis or carotid artery embolism ; 5 severe heart lung or renal insufficiency ; 6 Intracranial hemorrhage occurred in the past 1 year. 7 Patients with malignant tumors. Late stage of lower extremity sclerosing occlusive disease : 1 Participants who participated in other clinical trials in the past 2 months ; 2 pregnant and lactating women ; 3 Patients with malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabonomic;Stranscriptomic; | — |
Secondary
| Measure | Time frame |
|---|---|
| Low-Density Lipoprotein Cholesterol;C-reactive protein;Total Cholesterol;D- Dimer;High Density Lipoprotein Cholesterol;Activated Partial Thromboplastin Time;Fibrinogen;Numeric Rating Scale;Barthel Index;Homocysteine;Glucoes ;Vascular Quality of Life Questionnaire;Prothrombin Time;Thrombin Time;Triglyceride;Activated Partial Thromboplastin Time; | — |
Countries
China
Contacts
Public ContactYan Ying
Beijing University of Chinese Medicine Third Affiliated Hospital
Outcome results
None listed