Insomnia
Conditions
Interventions
Health interventions:taVNS stimulation combined slow pace brathing
Control group:taVNS stimulation
Healthy subjects:taVNS stimulation
Combined treatment group:taVNS stimulation combined slow pace brathing
Sponsors
Experimental Research Center China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.insomnia patient 1) Those who meet the diagnostic criteria for insomnia; 2) Aged 18-70 years old right-handed; (3) Pittsburg sleep quality index (PSQI) score =8 points and duration > 3 months; 2.Health control (1) physical health no serious heart brain liver kidney and other organ diseases; (2) age 18~ 70 years old; (3) mental mental illness such as psychosis cerebrovascular disease cognitive impairment and intracranial astrology; (4) no chronic disease somatic disease and the history of brain organic disease: no sleep disease (5) the cognitive function is normal and can understand and complete the test process. (6) non-nuclear magnetic resonance examination of contraindications;
Exclusion criteria
Exclusion criteria: 1. Insomniacs 1) Patients with severe physical diseases organic brain diseases and serious mental disorders; (2) Patients with severe primary diseases acute diseases infectious diseases and malignant tumors; 3) Sleep disorders caused by secondary insomnia poor sleep hygiene or other reasons 4)HAMD-17 scores > 17 points and HAMA-14 scores > 14 points; (5) Patients with magnetic resonance imaging (MRI) contraindications; 6) Pregnant and lactating women need to use tools to help them walk 2. Healthy subjects (1) Have stayed up late or worked shift in the past two weeks; (2) Patients with a history of headache or body pain; (4) No history of chronic diseases physical diseases and organic brain diseases: no sleep disorders (5) Pregnant women and breastfeeding nearly 3 months of planning;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Hamilton Depression Scale;Insomnia Severity Index;Fatigue Severity Scale;Epworth Sleepiness Scale;Dynamic brain network; resting Brian function;inflammatory factor; | — |
Countries
China
Contacts
Public ContactDai Jingang
Experimental Research Center China Academy of Chinese Medical Sciences
Outcome results
None listed