Helicobacter pylori infection
Conditions
Interventions
Experimental group:Qingre Huashi Compound granules once daily, rabeprazole 20mg/dose three times daily before three meals, amoxicillin capsule 1g tid, duration of treatment 10 days
Control group:Rabeprazole 20mg/dose three times daily before three meals
amoxicillin capsules 1g tid for 14 days
Sponsors
Peking University Firsty Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Positive carbon 13 or carbon 14 urea breath test ; 2)Age =60 years old; 3)Spleen and stomach dampness-heat syndrome; 4)Gastric malignant lesion is exclued by the gastroscopy in the past 3 months; 5)Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1) Have a history of Helicobacter pylori (HP) treatment; 2) Are allergic to the drugs used in the study; 3) Have other severe illnesses that could affect the evaluation of study results such as severe lung dysfunction uncontrolled hypertension diabetes coronary heart disease arrhythmia renal insufficiency (eGFR < 60ml/min/1.73m²) malignant tumors mental illness etc.; 4) Are taking other medications that may interact with the drugs used in this study; 5) Are unable to express subjective feelings or cooperate; 6) Have a history of antibiotic use within the last month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HP eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy index for spleen-stomach damp-heat syndrome;7-point Global Overall Symptom Scale; | — |
Countries
China
Contacts
Public ContactHui Ye
Peking University Firsty Hospital
Outcome results
None listed