Colon cancer
Conditions
Interventions
Research group:Oral administration of Gynostemma pentaphyllum saponin tablets on the basis of FOLF0X6 regimen or XELOX regimen treatment
Sponsors
Changzhou Second People's Hospital Jiangsu Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. According to the UICC/AJCC 8th edition TNM staging of colon cancer, the diagnosis of histopathology or cytology is IV Patients with stage colon malignant tumors; 2. Between the ages of 18 and 80; 3. At least one measurable lesion, according to RECIST 1.1 standard; 4. Frontline systemic anti-tumor treatment or entering the maintenance treatment stage; 5. ECOG score 0-1 points; 6. No autoimmune diseases; 7. Not using high-dose hormones and long-term antibiotics; 8. Expected survival time = 3 months;
Exclusion criteria
Exclusion criteria: 1. Unable to cooperate due to mental illness; 2. Have a history of immunodeficiency, or suffer from other acquired or congenital immunodeficiency diseases, or have a history of organ transplantation; Use high-dose glucocorticoids or immune transplant agents or long-term antibiotics within 3.4 weeks; Patients participating in other clinical trials within 4.4 weeks; 5. Patients with infectious pneumonia, non infectious pneumonia, interstitial pneumonia, and other conditions that require the use of corticosteroids; 6. Have a serious history of chronic autoimmune diseases, such as systemic lupus erythematosus, etc; A history of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease, and a history of chronic diarrhea diseases such as irritable bowel syndrome; Have a history of sarcoidosis or tuberculosis History; 7. Patients who do not follow medical advice, do not use medication according to regulations, or have incomplete information that can affect the judgment of efficacy or safety; 8. According to the researcher's judgment, there are accompanying diseases that seriously endanger patient safety or affect patient completion of the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival;Progression Free Survival; | — |
Countries
China
Contacts
Public Contactdingjie
Changzhou Second People's Hospital Jiangsu Province
Outcome results
None listed