seasonal allergic rhinitis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) The patient may experience 2 or more symptoms such as paroxysmal sneezing watery nasal discharge nasal itching and nasal congestion with symptoms lasting or accumulating for more than 1 hour per day and may be accompanied by eye symptoms such as tearing eye itching and redness; 2) The patient presents with common signs such as pale nasal mucosa edema and watery nasal secretions; 3) The patient must be positive for at least one allergen SPT and/or serum specific IgE or positive for nasal provocation test. 4) The symptoms are severe and have a significant impact on quality of life. Common allergens include seasonal inhalants such as pollen and fungi. 5) Age range: 18-65 years old; 6) Disease duration = 2 years; 7) Nose Symptom Score Scale TNSS score = 4 points; 8) Voluntarily participate in this study and be able to cooperate in completing the follow-up work of this study understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Potential subjects who meet the inclusion criteria will be excluded if they meet any of the following criteria. 1) Individuals with a history of chronic sinusitis or those diagnosed with chronic sinusitis through X-ray examination; 2) Individuals with organic lesions in the nasal cavity or those who have undergone nasal surgery before; 3) Patients with combined asthma or other respiratory diseases such as bronchiectasis malignant lung lesions etc; 4) Individuals with combined liver and kidney dysfunction severe mental and psychological disorders or other serious illnesses; 5) Individuals who are allergic to or dizzy with the drugs used in the study; 6) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total nasal symptom score;VIP\NPY\CGRP and NE;VIP\NPY\CGRP and NE;Time domain heart rate variability analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| nasal resistance and Nasal Cavity Volume;total non-nasal symptom score;visual analogue scale;Skin resistance value at the end of the upper limb;rhinoconjunctivitis quality of life questionnaire; | — |
Countries
China
Contacts
The Sixth Medical Center of PLA General Hospital