metabolism-associated fatty liver disease
Conditions
Interventions
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years male or female; 2.Diagnosis of hepatic steatosis by imaging (including ultrasound MRI or FibroScan) or liver histology; 3.Informed and signed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Combined with other liver diseases such as drug-induced hepatitis autoimmune liver disease alcoholic liver disease chronic hepatitis C hepatomegaly autoimmune liver disease and other liver diseases and end-stage liver disease; 3. Combined with infectious diseases such as viral hepatitis tuberculosis AIDS etc.; 4. Excessive alcohol consumption; 5. Drugs such as tamoxifen etamivir methotrexate sodium valproate and glucocorticoids and other drugs; 6. Combined with other serious systemic diseases such as coronary heart disease heart failure stroke renal insufficiency tumour serious infections etc.; 7. Major surgery or major stressful events in the past 2 months; 8. Weight fluctuation of more than 5% of one's own body weight in the past 3 months; 9. Taking drugs that cause liver injury in the past 3 months; 10. Taking drugs to treat steatohepatopathy or to correct metabolic disorders in the past 3 months. metabolic disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver hardness value (LSM);MRI-PDFF;Control Attenuation Index (CAP); | — |
Secondary
| Measure | Time frame |
|---|---|
| lipoprotein-associated phospholipase a2;apolipoprotein B;2-hour postprandial blood glucose;glutamic-pyruvic transaminase;visceral fat mass;glutamic oxaloacetic transaminase;Low density lipoprotein cholesterol;Fasting blood glucose;total cholesterol;body fat;Bilirubin value;waist circumference;Serum free fatty acids;Changes in Traditional Chinese Medicine Syndrome Score;Apolipoprotein A;Small and dense low-density lipoprotein cholesterol;glycosylated hemoglobin;High-density lipoprotein cholesterol;Fatty liver index;Tongue image parameters;body mass index;triglyceride;non-high-density lipoprotein cholesterol;Pulse diagnosis parameters;lipoprotein;Relative changes in patient weight before and after treatment (%); | — |
Countries
China
Contacts
Public ContactYuqun Cai
Zhejiang Provincial People's Hospital
Outcome results
None listed