Isolated diastolic hypertension
Conditions
Interventions
control group:Qingda granule simulant combined with lifestyle intervention
experimental group:Qingda Granules Combined with Lifestyle Intervention
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria of simple diastolic hypertension measured by blood pressure in the unified clinic with a hypertension classification of grade 1 and a risk stratification of low to moderate risk (refer to the Chinese Guidelines for the Prevention and Treatment of Hypertension Revised Edition 2024); (2) Did not take or did not take blood pressure medicine regularly within one month; (3) Chinese medicine diagnosis is in accordance with the syndrome of hyperactivity of liver and yang; (4) Between 20 and 75 years old (including boundary value)not limited to gender; (5)The person voluntarily participates in this study and signs the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with severe liver and kidney diseases (2) Combined unstable angina pectoris myocardial infarction acute cerebrovascular disease patients with heart failure severe psychiatric diseases hematopoietic diseases malignant neoplasms and other major illnesses patients; (3) Women who are pregnant or preparing for pregnancy in the last 6 months and women who are breastfeeding; (4) Secondary hypertension; (5) Have participated in or are participating in other clinical researchers in the past three months; (6) Suspected or definite allergy to the study drug. Those who met any of these were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Office diastolic blood pressure and home diastolic blood pressure change from baseline values before treatment, after 2 and 4 weeks of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ambulate blood pressure control before treatment, after 4 weeks of treatment;The change of the total score of TCM syndrome score before treatment, after 2 and 4 weeks of treatment;Office systolic blood pressure and home systolic blood pressure change from baseline values before treatment, after 2 and 4 weeks of treatment;The changes of hypertension hormones(Renin\Angiotensin II\ALD)before treatment, after 4 weeks of treatment;The changes of vasoactive substances(TXB2\ADM\PGI2\CGRP)before treatment, after 4 weeks of treatment;The change of VAS vertigo score before treatment, after 2 and 4 weeks of treatment;The change of duchenne hypertension life scale before treatment, after 2 and 4 weeks of treatment;The change of the score of TCM single syndrome score before treatment, after 2 and 4 weeks of treatment; | — |
Countries
China
Contacts
Public ContactLinzi Long
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed