the rebound pain after peripheral nerve block
Conditions
Interventions
Test group:Dexamethasone combined with comprehensive acupoint stimulation
Control group:Dexamethasone combined with the acupoint stimulation at sham acupoints or without embedding seeds and pressure
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: The orthopaedic patient with unilateral closed fracture of upper limb (humerus and below) in Xiangyang Central Hospital aged 18-80 years old ASA I-III grade who intend to undergo their first open reduction and internal fixation of unilateral fracture of upper limb (humerus and below) under brachial plexus block (intermuscular sulcus+axillary route).
Exclusion criteria
Exclusion criteria: 1: Patients with other site surgery 2: Emergency patients 3: Peripheral neuropathy preoperative operative upper limb with nerve injury 4: Previous axillary surgery on the operative side 5: Multiple operations on the upper limb of the surgical side (>1) 6: Patients with contraindications of local anesthesia drug allergy and postoperative analgesics (such as NSAID and paracetamol) 7: Pregnant patients 8: Patients with diabetes and vascular diseases; 9: long-term use of opioids antipsychotics antidepressants 10: Injection site infection acute porphyria or kidney disease requiring dialysis 11: Patients with contraindications to regional anesthesia general anesthesia and nerve block insufficiency to assist general anesthesia or change general anesthesia 12: Patients with chronic pain syndrome 13: Patients who are unable to understand the perioperative questionnaire (language problems or cognitive impairments) 14: Have participated in similar studies in the past three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS scores at 1 2 and 3 days after surgery (resting pain average daily pain most severe pain and night pain scores); | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of analgesia and motor block;Anxiety scores at 1 2 and 3 days after surgery;Expression levels of differential genes in peripheral blood before and after surgery;dosage of postoperative analgesics (opioids NSaids);postoperative side effects(headache dizziness nausea vomiting);Quality of sleep day 12 and 3;Daily resting pain average pain most severe pain and nighttime pain scores at days 7 and 30; | — |
Countries
China
Contacts
Public ContactGong Xingrui
Xiangyang Central Hospital
Outcome results
None listed