knee osteoarthritis
Conditions
Interventions
Experimental group:Oral celecoxib capsule and Zeling Guanjie Xiaozhong Mixture
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for knee osteoarthritis (KOA) according to Western medicine with a traditional Chinese medicine syndrome type of damp-heat obstruction syndrome; 2. Radiographic grading between Grade I and Grade III; 3. Age between 50 and 75 years inclusive with no gender restriction; 4. Understands and agrees to participate in this study and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with complications such as gout or rheumatoid arthritis affecting the joints; 2. X-ray findings indicating extensive osteophyte formation significant narrowing or disappearance of joint space or joint deformities; 3. Patients with valgus or varus deformity of the knee joint lower limb disability or in the advanced stage of the disease with loss of working ability; 4. Patients with disease caused by trauma or who have undergone local knee joint surgery; 5. Use of other types of anti-inflammatory analgesics or corticosteroids within the past month; 6. Presence of severe cardiovascular cerebrovascular gastrointestinal or hematological diseases; 7. Pregnant or planning to become pregnant or breastfeeding women; 8. Allergic to the study drug or having an allergic constitution.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Arthritis Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory cytokines;Visual analogue scale;Lequesne index;Quantitative Scoring Standard for Traditional Chinese Medicine Syndromes; | — |
Countries
China
Contacts
Public ContactQiugen Wang
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine
Outcome results
None listed