Premature ovarian insufficiency
Conditions
Interventions
Control group (placebo) :Placebo capsules, 4 capsules, tid, with warm water for 12 weeks.
Treatment group (Yangyin Shugan capsule) :Yangyin Shugan capsules, 4 capsules, tid, taken with warm water for 12 weeks.
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of traditional Chinese and western medicine; 2. Age: 18-40 years old female (excluding 40 years old); 3. Menstrual cessation time < 6 months; 4. Those who can sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Chromosomal abnormalities; 2. Patients with the following gynecological pelvic surgery history: ovarian cyst removal oophorectomy ovarian wedge resection salpingectomy tubal ligation etc. 3. The use of reproductive toxic drugs such as tripterygium wilfordii chemotherapy drugs or radiotherapy and other iatrogenic factors; (4) severe autoimmune and metabolic diseases; 5. Pregnancy and childbearing within the past six months. 6. Treatment with hormones selective estrogen receptor modulators aromatase inhibitors soy extracts etc. in the past 3 months; 7. Patients with a history of habitual use of antibiotics or use of antibiotics probiotics prebiotics or live micro-ecological bacteria preparations in the past 1 month; Laxatives or other drugs affecting gastrointestinal function; 8. Severe liver kidney heart and brain diseases; Patients with malignant tumors; People with severe mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bFSH;Menstrual score sheet; | — |
Secondary
| Measure | Time frame |
|---|---|
| bE2;Gut microbiota 16S-rDNA sequencing Gut microbiota 16S-rDNA sequencing;Metabolomics analysis of stool and blood;SAS;Blood immune cytokines;AMH;SDS;Modification of the KI scale;TCM syndrome scale;Transvaginal Ultrasound; | — |
Countries
China
Contacts
Public ContactHuang Xuchun
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed