Ankylosing spondylitis
Conditions
Interventions
Study group control group and healthy control group:On the basis of the control group combined with Hua Tuo's Five-Animal Frolics
Healthy control group:Hua Tuo's Five-Animal Frolics
Control group:Celecoxib capsules plus sulfasalazine treatment basis
Sponsors
The First Affiliated Hospital of Anhui University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meet the following diagnostic criteria: AS patients according to the New York criteria for the diagnosis of ankylosing spondylitis revised by the American Society of Rheumatology (ACA) in 1984 and the inflammatory low back pain (IBP) criteria established by the 2009 International Working Group for the Evaluation of spinal arthrosis (ASAS) and the new central axis SpA standard; (2) Age: 18-75 years old; (3) Patients with drugs (except SASP) such as triptrix prednisone (10mg) or other equivalent hormones should be stable for at least one month; (4) Voluntary participation in and actively cooperate with the treatment.
Exclusion criteria
Exclusion criteria: (1) Do not meet the following diagnostic criteria: AS patients according to the New York diagnostic criteria of ankylosing spondylitis revised by the American Society of Rheumatology (ACA) in 1984 and the inflammatory low back pain (IBP) criteria established by the 2009 International Working Group for Evaluation of spinal arthrosis (ASAS) and the new central axis SpA standard; (2) Combined with serious diseases such as heart liver and kidney and severe extra-articular manifestations; (3) those allergic to the study drug; (4) Advanced patients with severe joint deformity and rigidity and complete loss of joint function; (5) Patients with communication disorders and patients with other diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy evaluation;Disease activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| The expression of IL-17 / NF- ? B and Smad pathway;Bath Ankylosing Spondylitis Functional Index;Bath Ankylosing Spondylitis Disease Activity Index;Pillow-Wall Distance;Magnetic Resonance Imaging and Full Spine X-ray;Visual Analogue Scale for Patient's Overall Assessment;Bath Ankylosing Spondylitis Metrology Index;Schober's Test ; | — |
Countries
China
Contacts
Public ContactHuang Chuanbin
The First Affiliated Hospital of Anhui University of Chinese Medicine
Outcome results
None listed