Vascular Cognitive Impairment
Conditions
Interventions
control subjects:Donepezil hydrochloride, 1 tablet, 2 times a day
Chinese medicine group:Ginseng and Ma Yi Zhi Granules, 1 sachet at a time, 2 times a day, to be taken
Sponsors
Xiyuan Hospital, China Academy of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) 50 years old = age = 85 years old male or female, and confirmed by others (4) Meet the diagnostic criteria of Vascular Cognitive Impairment (VC-IND or VD (3) 11 scores = Brief Mental State Examination (MMSE) = 26 scores, and also satisfy the diagnostic criteria of Hachinski Ischemic Scale (HIS) > 7 scores) (5) Identify the diagnostic criteria of Chinese medicine for the syndrome of hyperactivity of liver and yang with deficiency of qi, blood stasis and blood stasis (6) Meet the requirements of this study. (7) have sufficient visual and auditory discrimination to undergo neuropsychological testing (8) have a certain level of education and have been able to read simple articles and write simple sentences (9) have a stable caregiver (10) have given informed consent and signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) People with other causes of dementia, including Alzheimer's disease, Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, brain tumors, progressive supranuclear palsy, epilepsy, chronic subdural hematoma, and multiple sclerosis, a history of severe head trauma with persistent neurological deficits, or a known structural abnormality of the brain (2) Thyroid disorders, vitamin B12 or folic acid deficiencies, severe anemia or malnutrition, severe cardiac, hepatic, pulmonary, or renal diseases, and other organ disorders affecting central nervous system functioning (3) Allergies (4) Concurrent use of cholinergic or anticholinergic medications and medications that have an effect on cognitive function (5) Depression, schizophrenia, and other psychiatric disorders (6) Alcoholism, long-term use of antipsychotic medications, and a history of severe head trauma (7) Failure to cooperate with the cognitive function test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| homocysteine (Cys);MMSE;Clinical Dementia Rating Scale;Ability to Perform Daily Living Skills Rating Scale;Alzheimer's Disease Rating Scale-Cognitive Items;5-Methyltetrahydrofolate homocysteine methyltransferase;Methylenetetrazolium folate reductase;Cystathionine beta-synthase; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM Symptom Integral Scale; | — |
Countries
China
Contacts
Public ContactLiu Meixia
Xiyuan Hospital, China Academy of Traditional Chinese Medicine
Outcome results
None listed