Myasthenia gravis
Conditions
Interventions
Western medicine treatment cohort:Western medicine treatment
TCM and western integrative cohort:Chinese medicine combined with western medicine treatment
TCM treatment cohort:TCM treatment
Sponsors
The Affiliated Hospital of Changchun University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
8 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age =8 years old gender unlimited; 2. Meet MG clinical diagnostic criteria; 3. Patients with myasthenia gravis whose clinical MGFA classification is type I II (IIa IIb) III (IIIa IIIb) IV (IVa IVb); 4. Agree to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with mental illness and lack of autonomous ability; 2. Subjects deemed by the investigator to be unable to complete the clinical investigation; 3. According to the judgment of the researcher there are other diseases or conditions that reduce the possibility of enrollment or complicate enrollment such as frequent changes in the working environment and unstable living environment which are easy to cause the loss of follow-up; 4. Patients who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QMG score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the discontinuation rate, reduction rate and use of cholinesterase inhibitors, glucocorticoids, immunosuppressants and other drugs from baseline;Change in myasthenia gravis Composite Scale (MG-C) score from baseline;Change from baseline in the Pittsburgh Sleep Quality Index (PSQI) score;Change in myasthenia gravis Daily Living Scale (MG-ADL) score from baseline;Change in food frequency questionnaire scores from baseline;Change of TCM Quality of Life Assessment Scale (CQ-D11) score from baseline;Change from baseline on the absolute and relative score of myasthenia gravis (ARS-MG);Change in myasthenia gravis specific muscle strength test (MMT) score from baseline;Change in Self-perceived Burden Scale (SPBS) score from baseline;Changes in self-rating scale for depression and self-rating Scale for anxiety from baseline;Change in myasthenia gravis daily living ability score (MG-QOL-15) from baseline; | — |
Countries
China
Contacts
Public ContactWang Jian
Changchun University of Chinese Medicine
Outcome results
None listed