idiopathic membranous nephropathy
Conditions
Interventions
Treatment Group:MoShenFuYuan granule treatment
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients with idiopathic membranous nephropathy confirmed by renal biopsy whose renal tissue or serum is positive for anti-PLA2R antibody; (2) Age =18 years old and =75 years old gender is not limited; (3) eGFR=60ml/min/1.73m2; (4) TCM syndroms are consistent with spleen-kidney qi deficiency and phlegm stasis interjunction syndrome; (5) After treatment with standard dose of ARB for more than 3 months the urinary protein quantity in 24 hours was still between 1.0-6.0g; In this experiment ARB was designated as irbesartan; (6) Voluntary subjects and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients who received glucocorticoids and immunosuppressants in the last 3 months including but not limited to leflunomide cyclophosphamide (CTX) cyclosporine tacrolimus mycophenolate ester rituximab etc; (2) Chronic liver disease heart dysfunction myocardial infarction stroke uncontrolled hypertension diabetes malignant tumors and other major diseases; (3) Systemic lupus erythematosus hepatitis B hepatitis C virus infection thyroid and other tumors organic solvents heavy metal poisoning and other clear secondary causes of membranous nephropathy; (4) pregnant (or pregnant within half a year) and lactating patients; (5) Known allergies or contraindications to some components of membranshenfuyuan granules.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour proteinuria;serum albumin;serum total protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;;Urinary microalbumin creatinine ratio;;Serum PLA2R antibody;serum urea nitrogen;;Estimate glomerular filtration rate;; | — |
Countries
China
Contacts
Public ContactRenHuan Yu
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed