Diminished Ovarian Reserve
Conditions
Interventions
Exposure group:Kidney tonifying Chinese medicine
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Between the ages of 20-40 years old the occurrence of thin menstruation small amount amenorrhea; 2) Married did not take contraceptive measures infertility period >1 year; 3) Patients with clinically diagnosed DOR (i.e. meet at least two of the following three criteria: 10 U/L 292.8 pmol/L And/or FSH/ luteinizing hormone (LH) >3.
Exclusion criteria
Exclusion criteria: 1) Patients with two or more previous spontaneous abortions (excluding biochemical pregnancy abortions) or three or more previous transplants Those who did not obtain clinical pregnancy; 2) Premature ovarian failure or ovarian gonadotropin resistance syndrome; Untreated uterine malformations or abnormalities: double uterus mediastinal uterus (complete or incomplete); Untreated hydrosalpinx on one or both sides (confirmed by hysterosalpingography); (5) Intrauterine adhesions endometriosis adenomyosis endometrial lesions (submucous fibroids submucous fibroids) Endometrial polyps uterine myoma > 4cm; 6) Polycystic ovary syndrome hyperprolactinemia hyperandrogenemia hypothyroidism adrenal gland Endocrine diseases such as functional abnormalities affect ovulation; 7) Infertility patients with abnormal ovarian function caused by immune factors genetic factors or congenital physiological defects; 8) Patients who have received pelvic radiotherapy; 9) Known or suspected sex hormone-related malignancies; 10) those who are allergic or intolerant to the drugs involved in the study; Assisted reproductive technology or contraindications to pregnancy such as uncontrolled liver and kidney dysfunction diabetes and hyperemia History of hypertension thyroid disease symptomatic heart disease moderate to severe anemia malignancy or thromboembolism or thrombosis Form a tendency to serious mental disorders acute infections of the genitourinary system sexually transmitted diseases with drug abuse and other serious Adverse habits exposure to teratogenic amounts of radiation poisons drugs and in the active period and the uterus does not have the function of pregnancy Or physical illness during pregnancy cannot sustain pregnancy; Take any other Chinese medicine or proprietary Chinese medicine that affects the evaluation of the efficacy of the drug within 30 days; Additional patients identified by the researchers as unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ovarian reserve function status of patients with DOR.;The situation of traditional Chinese medicine intake among patients with DOR (Diminished Ovarian Reserve);Outcome indicators of IVF-ET in patients with DOR.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate;number of oocytes retrieved;Live birth rate;Premature birth rate;Serum AMH level;Miscarriage rate; | — |
Countries
China
Contacts
Public ContactDong Li
Peking University Third Hospital
Outcome results
None listed