rheumatoid arthritis
Conditions
Interventions
Traditional Chinese and western medicine combined treatment group:Combined treatment of traditional Chinese and western medicine
Sponsors
Guang 'anmen Hospital China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age =18 years old; 2) meet the 2010 ACR/EULAR diagnostic criteria for RA; 3) Interstitial lung disease (ILD) diagnosed by HRCT; HRCT scans required the presence of fibrotic abnormalities affecting more than 10% of the area of the lung parenchyma with or without tractional bronchiectasis or honeycombing without evidence or suspicion of diagnosis when made by imaging specialty Home reading confirmed. 4) patients who can complete vital capacity (FVC) or carbon monoxide dispersion (DLCO) test (corrected for hemoglobin); 5)provide informed consent.
Exclusion criteria
Exclusion criteria: 1) ILD patients with other obvious causes such as SSC PSS HIV etc. 2) patients with significantly abnormal combined organ function; Liver: AST ALT ?-GGT > 10 times or > 1000U/L bilirubin > 5 times or > 100µmol/L or previous diagnosis of viral hepatitis; Kidney: creatinine clearance < 30ml/min; Lung: airway obstruction (pre-bronchodilator FEV1/FVC<0.7) pleural effusion accounting for more than 20% of pleural effusion severe pulmonary infection or other clinically significant pulmonary abnormalities; Cardiovascular: myocardial infarction within 6 months; Gastrointestinal tract: active peptic ulcer or bleeding; Hematological system: severe anemia leukopenia thrombocytopenia; Nervous system: patients with mental disorders; Cerebral thrombotic events (stroke and transient ischemic attack) within the previous year; 3) Tuberculosis cancer hereditary diseases and other diseases with poor prognosis; 4) patients during pregnancy and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes from baseline on high-resolution computed tomography (HRCT);FVC%;DLCO%; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of bone destruction progression in RA;Change from baseline in RA disease activity DAS-28;blood routine examination;The changes of inflammatory factors (CRP ESR) compared with baseline;The scores of Borg dyspnea index changed;hepatorenal function;Absolute change from baseline in the total score of the Kim's Brief Interstitial Lung Disease (K-BILD) questionnaire;urine routines; | — |
Countries
china
Contacts
Public Contactjiangquan
Guang 'anmen Hospital China Academy of Chinese Medical Sciences
Outcome results
None listed