Psoriasis
Conditions
Interventions
Control group:(1) For patients with mild to moderate psoriasis: Calcipotriol ointment
(2)For patients with severe psoriasis: Calcipotriol ointment+ Ezekizumab injection
Experimental group:(1) For patients with mild to moderate psoriasis: Celastrol
(2)For patients with severe psoriasis: Celastrol+ Ezekizumab injection
Sponsors
Yueyang Hospital of Intergrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for plaque psoriasis according to Western medicine; (2) Lesions cover = 15% BSA (Body Surface Area) (Lesions mainly located on the trunk and/or limbs, excluding palms/soles, face/scalp, and genital area); (3) Age between 18 and 65 years, regardless of gender; (4) Participants must agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Individuals with other active skin diseases that may affect the assessment of the condition; (2) Have received systemic investigational drugs biological agents or immunosuppressants within the past 2 months; (3) Have received topical corticosteroids phototherapy or other treatments within the past 2 weeks; (4) Currently experiencing severe uncontrolled local or systemic acute or chronic infections; (5) Individuals with a history of malignant tumors or primary or secondary immune deficiencies and hypersensitivity; (6) Have undergone major surgery within the past 8 weeks or are expected to require such surgery during the study period; (7) Pregnant or breastfeeding women; (8) Individuals with a history of alcohol abuse drug use or substance abuse; (9) Individuals with a history of severe mental illness or a family history of such conditions; (10) Individuals with a family history of tumors; (11) Other reasons deemed by the investigator to make the participant unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis Area and Severity Index(PASI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment efficacy rate;Relapse rate; | — |
Countries
China
Contacts
Public ContactKuai Le
Yueyang Hospital of Intergrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed