Post-infectious cough
Conditions
Interventions
Treatment group:Xingbei Zhike granules
Placebo group:Xingbei Zhike granules mimics agent
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) The patient met the diagnostic criteria for post-infectious cough; (2) The patient met the diagnostic criteria for the wind-heat invading lung TCM syndrome; (3) The duration of cough ranged from 3 to 5 weeks; (4) The cough VAS score=60mm; (5) Patients of both sexes were between 18 and 65 years of age (both ends included); (6) Patients gave informed consent and signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with a history of cough-related chronic lung disease including but not limited to gastroesophageal reflux disease bronchial asthma or cough variant asthma or chest tight-type asthma eosinophilic bronchitis acute or chronic sinusitis bronchial tuberculosis interstitial lung disease chronic bronchitis bronchiectasis chronic obstructive pulmonary disease bronchial lung cancer etc; (2) Patients with severe primary diseases of cardiovascular cerebrovascular liver kidney or hematopoietic system or with known immunocompromised or immunodeficiency diseases; (3) Patients with FeNO=32 ppb; (4) Patients with axillary temperature =37.3? or white blood cell count > 12×10^9/L and neutrophil percentage > 75%; (5) Patients whose serum Cr exceeded the upper limit of the reference value or patients with either ALT or AST exceeding 1.5 times the upper limit of the reference value; (6) Patients who quit smoking for less than 3 months; (7) Patients with suspected or confirmed history of alcohol or drug abuse or patients with cognitive impairment or severe mental illness who cannot cooperate with the completion of the clinical trial; (8) Women who are pregnant or planning to become pregnant within six months and lactating women; (9)Allergic patients such as those with a history of allergy to two or more drugs or foods or those who are known to be allergic to the ingredients of the drug used in the study; (10) Participants who had participated in any clinical trial within 3 months before the screening examination; (11) Patients who were judged by the investigator to be ineligible to participate in the trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The number and frequency of emergency medication use;The changes of cough evaluation test(CET) score on days 7 and 14 were compared with baseline;Change from baseline in Leichester Cough Quality of Life Questionnaire (LCQ) score;Changes in TCM syndrome scores from baseline to 7 days and 14 days after treatment;Changes in cough VAS scores from baseline to 7 days and 14 days;The disappearance time and rate of cough symptoms after treatment; | — |
Countries
China
Contacts
Public ContactLinLin
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed