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The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with acute mountain sickness: A double-blind, randomized, sham-controlled trial

Efficacy and safety of transcutaneous auricular vagus nerve stimulation on acute mountain sickness: A prospective randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2024000642
Enrollment
Unknown
Registered
2024-11-03
Start date
2024-11-15
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute mountain sickness

Interventions

Sponsors

Institute Of Basic Research In Clinical MedicineChina Academy Of Chinese Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 44 Years

Inclusion criteria

Inclusion criteria: (1) The altitude of the subjects during the study period was =3000m; (2) The time of reaching plateau was =48 hours; (3)LLSS score =5 points (at least 1 points for headache); (4) Age =18 years old < 45 years old; (5) No living and working experience at high altitude (=3000m) within 2 months; (6) Have not participated in other clinical trials within 3 months; (7) Voluntarily participated in this study and signed informed consent.

Exclusion criteria

Exclusion criteria: (1) Clinically defined high altitude pulmonary edema or high altitude cerebral edema before enrollment; (2) Those with chronic headache dizziness serious cardiovascular and cerebrovascular diseases respiratory system diseases and digestive system diseases before entering plateau; (3) Complicated with other serious diseases such as malignant tumors cognitive impairment and mental disorders that affect the evaluation of this study; (4) History of brain trauma brain space occupying lesions epilepsy or metal implantation in the head; (5) Skin inflammation damage or scar in the concha cavity; (6) Those who are pregnant lactating or have plans to become pregnant; (7)Use of antibiotics or probiotics in the past 8 weeks.

Design outcomes

Primary

MeasureTime frame
2018 Lake Louise Acute Mountain Sickness Score ;

Secondary

MeasureTime frame
the Stanford Sleepiness Scale;Incidence of AMS;Corsi task;Wechsler Memory Scale-picture memory;resting heart rate;AMS severity score;Peripheral oxygen saturation;Groningen Sleep Quality Questionnaire;Cerebral oxygen saturation;resting blood pressure;VAS of headache;

Countries

China

Contacts

Public ContactJia Liu

Institute Of Basic Research In Clinical Medicine China Academy Of Chinese Medical Sciences

marie_liujia@163.com18810877011

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026