Knee Osteoarthritis
Conditions
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of KOA set by American College of Rheumatology; 2. Male or female patients aged 40 years or older; 3. Mild to moderate radiographic medial tibiofemoral osteoarthritis (Kellgren - Lawrence score from 1 to 3 in at least one knee; 4. WOMAC pain score >= 40 (visual analog version range from 0 to 100 higher indicating more pain) on at least one of five questions for at least 1 month; 5.Volunteer to participate in the trial and provide written informed consent form. 6. right-handed; 7. Routine cranial magnetic resonance imaging examination showed no abnormality.
Exclusion criteria
Exclusion criteria: 1. History of knee surgery or combined with tumor tuberculosis osteomyelitis in knee joints; 2. Arthroscopy in the past 6 months or intra-articular injection of steroid or hyaluronic acid in the past 3 months; 3. Major medical or physical conditions determined by doctors to preclude exercise including serious acute or chronic organic diseases of cardiovascular hepatic renal cerebrovascular and hematopoietic systems recent stroke psychiatric disease active cancer; 4. Have participated in strength training more than 30 minutes per week in the past 3 months; 5. Have participated in other clinic trials in the past 4 weeks. 6. Patients with contraindications to MRI scanning (patients with pacemakers prosthetic heart valves or various metal implants); 7. Patients with claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change in WOMAC pain subscale between baseline and week 12; | — |
Secondary
| Measure | Time frame |
|---|---|
| rfMRI;Dosage of NSAIDs;WOMAC pain, stiffness, physical function subscales and the total score;DASS-21;SF-36; | — |
Countries
China
Contacts
Public ContactYao Fei
Shanghai Municipal Hospital of Traditional Chinese Medicine
Outcome results
None listed