Skip to content

The therapeutic efficacy of "selecting acupoints based on pain" Tuina intervention for knee osteoarthritis and the mechanism of action involving the PAG-Th circuitry

The therapeutic efficacy of "selecting acupoints based on pain" Tuina intervention for knee osteoarthritis and the mechanism of action involving the PAG-Th circuitry

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2024000635
Enrollment
Unknown
Registered
2024-11-01
Start date
2024-12-01
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Acupuncture group:Acupuncture

Sponsors

Shanghai Qingpu District Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for knee osteoarthritis (KOA) according to both traditional Chinese medicine and Western medicine; 2. Age between 40 and 70 years old with pain in the left knee and right-hand dominance; 3. Kellgren-Lawrence radiological grade of I-II; 4. Visual Analog Scale (VAS) score greater than 3 with a disease duration of no less than 3 months; 5. Have not received other treatments in the past 4 weeks; 6. Voluntarily participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Individuals with a history of trauma or surgery on the knee; 2. Individuals with tumors tuberculosis osteomyelitis or other diseases affecting the knee; 3. Individuals with severe liver or kidney dysfunction severe cardiovascular diseases diabetes or mental illnesses that may affect massage therapy; 4. Individuals with body pain caused by other diseases; 5. Individuals with a history of drug allergies; 6. Individuals with MRI contraindications such as claustrophobia pacemakers defibrillators heart stents intrauterine devices etc.; 7. Individuals with skin lesions around the knee joint.

Design outcomes

Secondary

MeasureTime frame
Muscle tension;Clinical efficacy;Western Ontario and McMaster Universities Osteoarthritis Index;Threshold of pain;10 meter walking time test;

Primary

MeasureTime frame
Short-Form McGill Pain Questionnaire;FMRI detection indicators;

Countries

China

Contacts

Public ContactChen Dong Gu

Shanghai Qingpu District Hospital of Traditional Chinese Medicine

764456305@qq.com13764712741

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026