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Clinical evidence-based study and mechanism discussion on the intervention of Bupleurum Xuanxuanhua Decoction on immune damage and metabolic disorder in Hashimoto patients with subclinical hypothyroidism

Clinical evidence-based study and mechanism discussion on the intervention of Bupleurum Xuanxuanhua Decoction on immune damage and metabolic disorder in Hashimoto patients with subclinical hypothyroidism

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2024000627
Enrollment
Unknown
Registered
2024-10-30
Start date
2024-08-16
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hashimoto thyroiditis with subclinical hypothyroidism

Interventions

treatment group:Use bupleuri Xuanlinghua Decoction 200ml instead of decoction twice a day one dose a day.
control group:Placebo (packaged in the same way as traditional Chinese medicine with added bitters). The method of administration was the same as that of experimental group.

Sponsors

Wangjing Hospital China Academy of Chinese Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) Those who meet the above diagnostic criteria of Chinese and Western medicine; (2) Adult patients aged 18-70 years old both male and female; (3) The person who signed the informed consent; 4)TSH value < 10mIU/L.

Exclusion criteria

Exclusion criteria: 1) Patients with a history of thyroid cancer; (2) Suffering from serious heart liver kidney blood system diseases or serious mental disorders; Pregnant or lactating women; 4) Allergic to drugs; (5) Subacute thyroiditis postpartum thyroiditis subclinical hypothyroidism after receiving hyperthyroidism-related treatment or after using drugs.

Design outcomes

Primary

MeasureTime frame
TCM symptom and syndrome integral;ThyPRO39;Thyroid function and antibodies;

Secondary

MeasureTime frame
manifest anxiety scale;ZUNG's Depression Scale;Total lipids;Glycosylated hemoglobin;

Countries

China

Contacts

Public ContactWang Bo

Wangjing Hospital China Academy of Chinese Medical Sciences

sherrygxh@126.com15801290334

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026