Unexplained Recurrent Spontaneous Abortion
Conditions
Interventions
Exposure group:For the first trimester, take Formula A orally plus a daily multivitamin with folic acid, three weeks monthly. Skip Formula A during menstruation and use barrier contraception. Try to c
Non-exposure group:For the three months before pregnancy,take a multivitamin orally (containing folic acid, 1 tablet per day). Use barrier contraception and start trying to conceive after three months
Sponsors
The First Affiliated Hospital of Henan University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: ?In line with early URSA Western medicine diagnosis criteria ?Meet the diagnostic criteria for the syndrome of Kidney Deficiency and Blood Stasis-Heat in recurrent miscarriage ?Aged 18 to 40 years ?Voluntarily participate in this study and sign the informed consent form
Exclusion criteria
Exclusion criteria: ?Oral administration of other Chinese herbal medicines or proprietary Chinese medicines (with formulations similar to the studys compound) ?Combined with severe diseases of the digestive system endocrine diseases (hyperthyroidism hypothyroidism diabetes etc.) respiratory system diseases hematological diseases urinary system diseases nervous system diseases and mental illnesses. ?Uncontrolled hypertension(=160/100mmHg) or hypotension (systolic blood pressure < 95 mmHg) ?Abnormal liver or kidney function ?Patients who have used hormone or immunosuppressive drugs within the past 3 months prior to the study ?Participation in other clinical studies involving drugs within the past month and during the course of medication ?Insufficient exposure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Continuous pregnancy rate at 12 weeks gestation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of depression/anxiety;Clinical pregnancy rate;Live birth rate;Obstetric complications;Ectopic pregnancy rate;Abortion rate;Biochemical pregnancy rate;Preterm birth rate;Effectiveness rate of traditional Chinese medicine treatment; | — |
Countries
China
Contacts
Public ContactChenPing
The First Affiliated Hospital of Henan University of Chinese Medicine
Outcome results
None listed