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Efficacy and Safety of the Zhi-Chuan-Ling oral liquid on Asthma-COPD overlap (ACO): a randomized double-blind placebo-controlled trial

Efficacy and Safety of the Zhi-Chuan-Ling oral liquid on Asthma-COPD overlap (ACO): a randomized double-blind placebo-controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2024000587
Enrollment
Unknown
Registered
2024-10-21
Start date
2024-10-31
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma-COPD overlap

Interventions

ZCL group:basic treatment+ZCL oral liquid

Sponsors

China-Japan Friendship Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) patients who meet the diagnostic criteria of ACO (2) stable patients without hospital admissions for acute exacerbations in the past 3 months (3) patients with CAT score=10 (4) patients aged between 40 and 80 years (5) patients with informed signed consent and voluntary participation in the study.

Exclusion criteria

Exclusion criteria: (1) patients diagnosed with GOLD IV (2) patients diagnosed with upper or lower respiratory tract infection; tuberculosis; pulmonary interstitial fibrosis; thoracic malformation bronchiectasis; cystic pulmonary fibrosis; allergic bronchopulmonary aspergillosis; eosinophilic granulomatous vasculitis; and other airflow obstructive lung diseases (3) patients diagnosed with serious heart; brain; liver; kidney; immune or blood system disease (4) patients whose scr exceeds the upper limit of the reference value or AST and ALT= 2 times the upper limit of the reference value (5) patients who are allergic to the ZCL oral liquid (6) pregnant or breast-feeding women; or women during childbearing years who do not have contraception (7) patients enrolled in other clinical trials during the previous 3 months (8) patients who are known or suspected of a history of alcohol or drug abuse (9) patients with any kind of mental illness

Design outcomes

Primary

MeasureTime frame
FEV1 %pred;

Secondary

MeasureTime frame
TNF-a;lung function;EOS;IL-6;CAT score;symptom score;

Countries

China

Contacts

Public ContactDemin Li

China-Japan Friendship Hospital

demin2008@sina.com13811830348

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026