patients with IVF-ET failure
Conditions
Interventions
Control:Bu Xue Yi Mu Wan placebo+HRT therapy
Test group:Bu Xue Yi Mu Wan+HRT therapy
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1.Age 20-38 years (inclusive of boundary values 2. Body mass index 18.5 = BMI < 30.0 kg/m² 3. Failed first IVF/ICSI embryo (1 fresh or frozen embryo) transfer cycle 4.Conforms to the TCM syndrome of "Qi and blood deficiency with blood stasis" (qualitative judgment: at least one main symptom and at least two secondary symptoms must be met for diagnosis) 5.=1 D5-6 blastocysts (4BC or above) stored in the center
Exclusion criteria
Exclusion criteria: 1.Polycystic ovary syndrome (PCOS) diagnosed according to the Rotterdam criteria 2.History of recurrent miscarriage (defined as 2 or more consecutive pregnancy losses before 28 weeks of gestation with the same partner including biochemical pregnancies) 3.Unhealed intrauterine adhesions endometrial polyps 4. Uterine adenomyosis uterine fibroids compressing the uterine cavity line endometriosis (previously diagnosed as ASRM III-IV stage by surgery) 5.Uterine structural abnormalities including septate uterus unicornuate uterus bicornuate uterus 6.Visible tubal hydrosalpinx under ultrasound that has not been treated 7. Patients with diseases that are currently unsuitable for assisted reproductive technology or pregnancy 8.History of autoimmune diseases such as antiphospholipid syndrome systemic lupus erythematosus rheumatism etc. and patients withthrombophilia 9. Patients who have taken TCM or patent Chinese medicine for infertility-related conditions within 14 days before randomization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate;Traditional Chinese Medicine (TCM) syndrome score;Endometrial thickness;Embryo implantation rate;Endometrial morphology;Subendometrial blood flow grading;Early miscarriage rate;Biochemical pregnancy rate; | — |
Countries
China
Contacts
Public ContactHuang Hefeng
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed