Post-stroke Aphasia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Western medical diagnosis of cerebral infarction, onset 1-6 months, age 35-80 years old; (2) native Chinese, right-handed, elementary school education or above; (3) clear aphasia symptoms, non-fluent aphasia on the WAB scale, and a score of =2 on the Boston Diagnostic Aphasia Examination (BDAE) aphasia severity scale; (4) clear consciousness and a score of >10 on the Minimum Mental State Examination (MMSE); (5) available to cooperate with a 40-minute MRI and serologic examination, and signing an informed consent form in accordance with ethical requirements.
Exclusion criteria
Exclusion criteria: (1) Severe hearing impairment, cognitive impairment, etc., resulting in the patient's inability to cooperate with the scale assessment; (2) Speech and language disorders due to disorders of consciousness and general mental retardation; (3) Learning difficulties due to congenital or early childhood diseases, resulting in speech and language deficits; (4) Combination of cardiovascular, hepatic, renal, immune system, and other serious primary diseases, tumors, and psychiatric diseases; (5) Those who are being treated with transcranial direct current stimulation therapy, taking drug therapy with piracetam, donepezil, memantine, bromocriptine, and galantamine, and who are unable to discontinue this therapy after inclusion in the study; (6) Presence of contraindications to MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Aphasia Battery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;correlation index of magnetic resonance imaging analysis;serological indicators of neuroplasticity; | — |
Countries
China
Contacts
Dongzhimen Hospital, Beijing University of Chinese Medicine