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Exploring the Mechanism of Neuroplasticity Effect of Yi Sui Xing Shen Acupuncture Rehabilitation Treatment on Post-stroke Aphasia Based on the HPA-Hippocampus-Papez Loop

Exploring the Mechanism of Neuroplasticity Effect of Yi Sui Xing Shen Acupuncture Rehabilitation Treatment on Post-stroke Aphasia Based on the HPA-Hippocampus-Papez Loop

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2024000486
Enrollment
Unknown
Registered
2024-09-26
Start date
2024-10-01
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke Aphasia

Interventions

Group B:basic treatment in internal medicine, cognitive rehabilitation training and acupuncture(The position of acupuncture is not the acupoint nor the meridian circulation.) combined treatment
Group A:basic treatment in internal medicine,cognitive rehabilitation training and Yi Sui Xing Shen acupuncture program combined treatment

Sponsors

Dongzhimen Hospital Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Western medical diagnosis of cerebral infarction, onset 1-6 months, age 35-80 years old; (2) native Chinese, right-handed, elementary school education or above; (3) clear aphasia symptoms, non-fluent aphasia on the WAB scale, and a score of =2 on the Boston Diagnostic Aphasia Examination (BDAE) aphasia severity scale; (4) clear consciousness and a score of >10 on the Minimum Mental State Examination (MMSE); (5) available to cooperate with a 40-minute MRI and serologic examination, and signing an informed consent form in accordance with ethical requirements.

Exclusion criteria

Exclusion criteria: (1) Severe hearing impairment, cognitive impairment, etc., resulting in the patient's inability to cooperate with the scale assessment; (2) Speech and language disorders due to disorders of consciousness and general mental retardation; (3) Learning difficulties due to congenital or early childhood diseases, resulting in speech and language deficits; (4) Combination of cardiovascular, hepatic, renal, immune system, and other serious primary diseases, tumors, and psychiatric diseases; (5) Those who are being treated with transcranial direct current stimulation therapy, taking drug therapy with piracetam, donepezil, memantine, bromocriptine, and galantamine, and who are unable to discontinue this therapy after inclusion in the study; (6) Presence of contraindications to MRI.

Design outcomes

Primary

MeasureTime frame
Western Aphasia Battery;

Secondary

MeasureTime frame
Montreal Cognitive Assessment;correlation index of magnetic resonance imaging analysis;serological indicators of neuroplasticity;

Countries

China

Contacts

Public ContactChang Jing-ling

Dongzhimen Hospital, Beijing University of Chinese Medicine

ear6979@163.com+86 186 1118 1701

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026