Nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:Compound vitamin B12 solution + Dendrobium officinale tea drink. Dendrobium officinale 12g (provided by Zhejiang Cancer Hospital Pharmacy), decocted to 600ml by pharmacy machine, di
Control group:Gargle with compound vitamin B12 solution 3 times/day. Do not gargle within 30 minutes after medication. Fast and water should be prohibited. Treatment for 1 month is a course of treatme
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age 30 to 50 years old; 2) Confirmed diagnosis of nasopharyngeal carcinoma by pathology; (3) Patients who meet the diagnostic criteria of radiation oral mucositis in Western medicine; (4) Patients without obvious oral pharyngitis symptoms and oral mucosal injury before radiotherapy; 5) Sign informed consent and agree to join the cohort.
Exclusion criteria
Exclusion criteria: 1) Serious diseases combined with non-malignant tumors will affect the patient's compliance or put the patient in a dangerous state; 2) Accompanying other anti-tumor therapies or participating in other clinical trials; Patients using antibiotics: included those who had received systemic high dose of antibiotics within 3 months before enrollment those who had long-term systemic use of antibiotics or those who had long-term use of antibacterial mouthwash. 4) Patients who use other drugs for oral mucositis at the same time; 5) Patients with Behcet's disease systemic lupus erythematosus diabetes and other diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune factor;Oral flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome score;Acute radiation oral mucositis scale;Immune-related factor;Immune-related factor IL-10;Salivary flow rate;Immune-related factor IL-11; | — |
Countries
China
Contacts
Public ContactAiqin Zhang
Zhejiang Cancer Hospital
Outcome results
None listed