Breast cancer
Conditions
Interventions
Control group:Aerobic exercise for twelve weeks
Treatment group:Baduanjin practice for twelve weeks
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
50 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Female aged50-70 years old in accordance with postmenopausal status: had undergone bilateral oophorectomy; Be aged 60 years or older; Age < 60 years old without drug castration (such as gonadotropin-releasing hormone) and the follicle stimulating hormone estradiol level in postmenopausal range; 2. Non-metastatic estrogen receptor positive and/or progesterone receptor positive early breast cancer confirmed by postoperative pathology stable endocrine therapy for =3 months and the remaining time of treatment =6 months and no other treatment such as radiotherapy or chemotherapy at the present stage; 3. Meet the diagnostic criteria of metabolic-associated fatty liver disease; 4. Abdominal ultrasound or imaging or liver histological examination suggested liver fat accumulation; 5. Meet the diagnostic criteria of qi deficiency and blood stasis syndrome of TCM; 6. Regular exercise <120 minutes per week within 3 months (e.g. continuous brisk walking jogging dancing cycling playing ball etc.); 7. Patients voluntarily participated in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Have a history of acute or chronic viral liver disease autoimmune liver disease alcoholic liver disease hepatolenticular degeneration and other specific liver diseases that can lead to fatty liver; And drugs (ethylamiodarone sodium valproate methotrexate glucocorticoids etc.) total parenteral nutrition inflammatory bowel disease celiac disease hypothyroidism Cushing's syndrome beta-lipoprotein-deficiency lipoatrophic diabetes Mauriac syndrome and other special cases leading to fatty liver; 2. Complicated with ascites or hepatic encephalopathy or liver fibrosis or cirrhosis; 3. Received traditional exercises such as Baduanjin or Yijinjing or Tai Chi in the past 3 months; 4. Patients with unstable weight (weight loss or gain of more than 4kg in the past 3 months); 5. Current use of weight-loss medications (e.g. orlistat) or previous weight-loss (metabolic) surgery; 6. Patients with spinal cord injury spinal cord symptoms severe heart brain and lung diseases etc. unable to participate in the exercise program; 7. Had a stroke or myocardial infarction in the past year; 8. Patients with dementia bipolar disorder and other major mental diseases language disorders or other reasons can not cooperate with the study or refuse to take blood; 9. Being ready for pregnancy or pregnant or lactating (ruled out by urinary HCG); 10. Current smokers; 11. Combined with any other malignant tumors; 12.Patients with distant metastasis of breast cancer especially bone metastasis; 13. Allergy to the study drug or its excipients; 14. Who participated in other clinical trials during the same period or within the previous 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| magnetic resonance imaging proton density fat fraction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;Plasma high-sensitivity C-reactive protein levels;glycosylated hemoglobin;blood lipid;Homeostasis model evaluation - Insulin resistance index;Multidimensional Fatigue Symptom scale-Short form;body composition;inflammatory cytokines;attendance rate;fasting blood-glucose; | — |
Countries
China
Contacts
Public ContactSheng Jiayu
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine
Outcome results
None listed