type 2 diabetes mellitus
Conditions
Interventions
Experimental group:At the same time of basic treatment of diabetes modified Gegenqinlian decoction combined with adequate metformin tablets was given
Control group:At the same time of basic treatment of diabetes adequate metformin tablets were given
Sponsors
Chengdu Shuangliu District Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) aged between 18 and 70 years old (2) patients with type 2 diabetes who met the diagnostic and classification criteria of diabetes (3) body mass index over 24.0kg/m2 (4) Poor glycemic control after lifestyle intervention {7.0%= glycosylated hemoglobin =9.0% and fasting blood glucose (FBG) =11.1mmol/L} (5) those who voluntarily participated in the study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) patients with type 1 diabetes; Patients with latent autoimmune diabetes in adults malignant tumors or other autoimmune diseases (2) patients with gastrointestinal and/or periodontal diseases; (3) acute diabetic complications including diabetic ketoacidosis diabetic hyperosmolar nonketotic coma hypoglycemic coma or severe unconscious hypoglycemia; (4) patients with heart failure unstable angina pectoris severe arrhythmia and myocardial infarction in the past 12 months; Blood pressure SBP > 180mmHg or DBP > 100mmHg; (5) history of liver disease such as cirrhosis hepatitis B or C (except carriers) or AST or ALT higher than 2.5 times the upper limit of normal; (6) history of renal disease or clinical diagnosis of renal insufficiency serum creatinine > 1.5mg/dl (132.6µmol/L); (7) patients with other endocrine system diseases such as hyperthyroidism hypercortisonism etc.; (8) those who are suffering from severe trauma severe infection or undergoing surgery and those who have received treatment but have not fully recovered; (9) patients with mental disorders drug or other substance abuse or alcoholism; (10) patients receiving steroid therapy or receiving treatment for malignant tumors; (11) Allergic constitution or allergic to the drugs used in the study; (12) pregnant lactating women women of childbearing age who have not taken effective contraceptive measures or plan to become pregnant during the trial and the urine HCG test result is positive;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diamine oxidase;The autophagy-related protein Atg7;HbA1c;blood fat;Serum lipopolysaccharide;Blood sugar;Neutrophil gelatinase-associated lipocalin;insulin release test;D-lactic acid;standard glucose tolerance test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Satiety index;HOMA islet ß cell function index;insulin sensitivity index;TCM syndrome score;HOMA insulin resistance index; | — |
Countries
CHINA
Contacts
Public ContactFANG WEI
Chengdu Shuangliu District Hospital of Traditional Chinese Medicine
Outcome results
None listed