Subthreshold depression
Conditions
Interventions
Sponsors
Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Healthy people: (1) Meet the World Health Organisation's criteria for a healthy person (2) Aged 18-65 years old; (2) No organic disease has been diagnosed; (3) Hamilton Depression Scale (HAMD-17) score: HAMD-17 total score <7; (4) Center for Epidemiologic Studies Depression Scale (CES-D): CES-D score <16; (5) Voluntarily participate in this study and sign an informed consent form; (6) Have not been involved in other research projects in the last month that could affect the results. 2. Patients with subthreshold depression (1) Meet the diagnostic criteria of SD; (2) Aged 18-65 years old ; (3) Hamilton Depression Scale (HAMD-17) score: 7 = HAMD-17 total score <17; (4) Center for Epidemiologic Studies Depression scale (CES-D): CES-D score = 16; (5) Voluntarily participate in this study and sign an informed consent form; (6) Have not been involved in other research projects in the last month that could affect the results. 3. Patients with depression: (1) Meet the diagnostic criteria of depression; (2) Aged 18-65 years old ; (3) Hamilton Depression Scale (HAMD-17) score: HAMD-17 total score = 17; (4) Center for Epidemiologic Studies Depression Scale(CES-D): =16 on the CES-D; (5) Voluntarily participate in this study and sign an informed consent form; (6) Have not been involved in other research projects in the last month that could affect the results.
Exclusion criteria
Exclusion criteria: (1) Those who are unconscious or unable to express subjective symptoms of discomfort or suffer from mental illness; (2) Those with progressive malignant tumors or other severe consumptive diseases, easily suffer from infections and bleeding; (3) Those with cardiovascular, or hepatic, or renal, or digestive, or hematopoietic system and other primary diseases; (4) Pregnant and lactating women; (5) Those who have bad breath dental caries (white spot lesions of enamel or dentin lesions) , or periodontal disease,or clinical symptoms of oral mucosal diseases; (6) Wearing removable or fixed prosthetic appliances; (7) Consumption of antibiotic and/or probiotic preparations within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of depression at the 6-month follow-up;Chinese 14-Item Perceived Stress Scale;Pittsburgh sleep quality index;Patient Treatment Expectation Assessment;Short Form 12-item Health Survey;Center for Epidemiologic Studies Depression Scale; | — |
Countries
China
Contacts
Public ContactTingting Ma
Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed