Thyroid Associated Ophthalmopathy
Conditions
Interventions
Glucocorticoid group:Glucocorticoid orbital injection combine with standard treatment
Control Group:standard treatment
Sponsors
Eye and ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age from 18 to 80 (2) subjective symptoms history of TAO=12months (3) CAS 1 or 2 (4) mild moderate-to-severe GO by EUGOGO (5) I-III by NOSPECS (6) cooprate with follow-up and treatment for at least 3months.
Exclusion criteria
Exclusion criteria: (1) any treatment in recent 3 months (2) NOSPECS=IV (3) any condition need systemic treatment in binocular TAO participants (4)any allergy history of triamcinolone acetonide dexamethasone or similar drugs (5) pregnant or lactating women (6)any surgical history of the observation eye (7) any eyeball or orbit penetrating injury history of the observation eye.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRD1/2;CAS score;PFH; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diplopia score;TCM score;TBUT;Schirmer I Test;Confocal microscopy outcomes;Eye movement;Inflammation factors in tear;AS-OCT outcomes;LTMH;Exophthalmos;Prognosis;Life quality score; | — |
Countries
The People's Republic of China
Contacts
Public ContactQIAN Jiang MO Xiaofen
Eye and ENT Hospital of Fudan University
Outcome results
None listed