rectal cancer
Conditions
Interventions
Baikudongfang Group:Baikudongfang
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1: Age = 18 years. 2: Pathology confirmed the diagnosis of adenocarcinoma of the rectum. 3: Locally advanced (T3-T4 or N+) diagnosed by CT MRI and/or ultrasound endoscopy. 4: Subjects must have adequate organ function as assessed by laboratory findings 5: Men of childbearing potential and women of childbearing potential must agree to use effective contraception from the time of signing the informed consent until 180 days after the end of concurrent radiotherapy. Females of childbearing potential include premenopausal females and females within 2 years of menopause. Women of childbearing potential must exclude pregnancy prior to concurrent radiotherapy.
Exclusion criteria
Exclusion criteria: (1) Patients with severe bleeding tendency and severe infection. (2) Patients who cannot cooperate with continuous follow-up. (3) Other primary malignancies other than radically treated locally curable malignancies (e.g. basal or squamous cell skin cancer superficial bladder cancer or carcinoma in situ of the prostate cervix or breast) that have developed within 5 years prior to synchronous radiotherapy. (4) Have uncontrollable co-morbidities including but not limited to symptomatic congestive heart failure uncontrollable hypertension unstable angina pectoris cardiac arrhythmia active peptic ulcers or bleeding disorders. (5) Patients with a history of alcohol or drug abuse. Translated with DeepL.com (free version)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CR Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| anal retention rate;Tumor downstaging rate;overall survival;median overall survival;2-year localized regional control rate;disease free survival; | — |
Countries
China
Contacts
Public ContactWang Hao
Peking University Third Hospital
Outcome results
None listed