Type 2 diabetes combined with lower extremity atherosclerosis disease
Conditions
Interventions
control group: Give Yiqi Yangyin and Huoxue compound granules simulator
treatment group:Give Yiqi Yangyin and Huoxue compound granules
Sponsors
Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age =65 and =80 years old no gender limit; (2) Meet the diagnostic criteria for type 2 diabetes and lower limb atherosclerosis; (3) The severity of LEAD belongs to Fontaine stage I-III; (4) Meet the diagnostic criteria of traditional Chinese medicine syndrome of "Qi and Yin deficiency combined with blood stasis"; (5) Voluntarily participate in this study and obtain written informed consent from respiratory patients or authoritative representatives.
Exclusion criteria
Exclusion criteria: (1) Combined with other vascular system diseases or related diseases affecting lower limb activity, such as: thromboangitis, Takayasu arteritis, arterial embolism, Raynaud's disease, lumbar spinal stenosis, etc.; (2) Patients with acute coronary syndrome, severe heart failure (cardiac function class III to IV), cardiomyopathy, and poorly controlled hypertension (systolic blood pressure =180 mmgh or diastolic blood pressure =110 mmgh); (3) Those combined with autoimmune diseases, malignant tumors, radiotherapy and chemotherapy, thyroid and parathyroid diseases, and blood system diseases; (4) Those who have undergone lower limb revascularization within the past year; (5) Obvious liver function damage has occurred in the past 6 months (alanine aminotransferase (ALT) or aspartate aminotransferase (AST) = 3 times the upper limit of normal); (6) There are contraindications for 6-minute walking (such as abdominal aortic aneurysm >4cm, heart surgery, myocardial infarction in the past month, unstable angina, resting heart rate >120 beats/min, systolic blood pressure >180mmHg, diastolic pressure>100mmHg); (7) Pregnant and lactating women; (8) Those who are allergic to or have contraindications to the drugs or ingredients in this study; (9) Those who have participated or are participating in other clinical trials in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial-ankle artery pulse wave velocity;Traditional chinese medicine syndrome score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Traditional Chinese Medicine Symptom Score;Hemoglobin A1c;Six-minute walk test;Vascular quality of life questionnaire-6;Total cholesterol;High-density lipoprotein cholesterol;Fasting plasma glucose;Ankle brachial pressure index;Low-density lipoprotein cholesterol;Triglyceride; | — |
Countries
China
Contacts
Public ContactYing Zhang
Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences
Outcome results
None listed