Reflux cough
Conditions
Interventions
Observation group:The observation group was given Beimu Zhizhu Granules (mainly composed of 10g of bran fried Fructus Aurantii, 12g of bran fried Atractylodes macrocephala, 15g of Poria cocos, 3g of C
Oral administration of omeprazole enteric coated capsule mimetic, 1 capsule per time, once daily, 30 minutes before breakfast. The treatment pe
Control group:The control group was given omeprazole enteric coated capsules orally, 20mg each time, once a day, 30 minutes before breakfast
Beimu Zhizhu Granules Simulated Oral Administration, 1 dose per day, diluted with 50-100ml water, taken 30 minutes after breakfast and dinner. The treatment period is 8 weeks.
Sponsors
Wangjing Hospital China Academy of Chinese Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Individuals who meet the diagnostic criteria for reflux cough in both traditional Chinese and Western medicine; 2) In the past 4 weeks, have not taken with cough, anti-reflux, acid inhibition effect of Chinese medicine/proprietary Chinese medicine/Western medicine; Age =18 years old; 4) Voluntarily accept the treatment plan and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Merge other cough causing diseases; 2) Merge severe primary diseases such as cardiovascular, cerebrovascular, liver and kidney, hematopoietic and endocrine systems, and malignancy Tumor patients and high-risk individuals for fractures; 3) Pregnant and lactating women; 4) Individuals who have participated or are currently participating in other clinical trials within the past month; 5) Taking warfarin, clopidogrel, aspirin, fenavir/azavir/nefenavir/ Shaquinavir, tacrolimus, voriconazole/posaconazole/ketoconazole/itraconazole, erlotinib, ciloconazole Tazole, diazepam, digoxin, methotrexate, phenytoin, nifedipine, rifampicin, St. John's wort and other drugs Objects; 6) Individuals who are known to be allergic to the treatment drugs specified in the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough evaluationg test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Color Doppler gastrointestinal contrast ultrasound;Leicester cough questionnair;Salivary bile acid;Salivary pepsin;Reflux Cough Rating Scale; | — |
Countries
China
Contacts
Public ContactWang Bin
Wangjing Hospital of the Chinese Academy of Traditional Chinese Medicine
Outcome results
None listed