Skip to content

Regulation of SST-cAMP-CREB signalling pathway by miR615-5p adsorbed by circRNA4928 affects gastric inflammation-cancer transformation and the mechanism of intervention of the method of Jianpihuoxuejiedu Decoction

Regulation of SST-cAMP-CREB signalling pathway by miR615-5p adsorbed by circRNA4928 affects gastric inflammation-cancer transformation and the mechanism of intervention of the method of Jianpihuoxuejiedu Decoction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2024000329
Enrollment
Unknown
Registered
2024-08-29
Start date
2021-01-01
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic atrophic gastritis

Interventions

chronic atrophic gastritis:no
chronic Non-Atrophic Gastritis:no
gastric adenocarcinoma:no
Precancerous lesions of gastric cancer:no

Sponsors

GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE,HAINAN HOSPITAL
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1)Age over 35 years old gender is not limited. 2) The disease diagnosis of chronic non-atrophic gastritis chronic atrophic gastritis gastric precancerous lesion gastric adenocarcinoma is clearly defined by gastroscopy and pathological histological examination of gastric mucosa. 3)Can carry out normal verbal communication and exchange. 4)Informed consent and volunteer to be tested.

Exclusion criteria

Exclusion criteria: 1) Receiving drug therapy study within the last 1 month. 2) Combined autoimmune gastritis (type A chronic atrophic gastritis) peptic ulcer (stage A1-H2) reflux oesophagitis gastric polyp hypertrophic gastritis ulcerative colitis and other diseases. 3) Those with non-gastric adenocarcinoma such as gastric ring cell carcinoma cardia carcinoma gastric mucous cell carcinoma etc. 4)Malignant tumours for which surgery radiotherapy and chemotherapy have been performed within the last 5 years. 5)Combined serious organic diseases. For example: heart (cardiac function NYH class III-IV haemodynamically unstable myocardial infarction etc.) liver (cirrhosis decompensated stage etc.) kidney (chronic renal failure uremic stage etc.) lungs (tuberculosis acute asthma attacks lung infections etc.) autoimmune system (systemic lupus erythematosus in active stage). 6)Allergies or hypersensitivity to multiple medications. 7)Those with comorbid serious mental illnesses that are unable to cooperate with the study such as schizophrenia depression anxiety disorders and dementia. 8)Pregnant breastfeeding women 9)Investigate non-cooperators.

Design outcomes

Primary

MeasureTime frame
TCM syndrome information;Gastroscope Report;Pathological Report;Key molecular markers(circ4928miR615-5pSST);

Secondary

MeasureTime frame
Epidemiological information;Prognostic information;

Countries

China

Contacts

Public ContactPanJinglin

GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE,HAINAN HOSPITAL

280705698@qq.com18818840586

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026