Glycolipid Metabolic Diseases
Conditions
Interventions
Non diabetic group with damp heat syndrome:N/A
Diabetes mellitus patients with syndrome of damp-heat:N/A
Diabetes non damp heat syndrome group:N/A
Sponsors
Dongzhimen Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Inclusion Criteria for Diabetic Patients with Damp-Heat Syndrome 1) Age range from 18 to 75 years old, regardless of gender; 2) Meet the diagnostic criteria for Type 2 Diabetes Mellitus (T2DM) and the diagnostic criteria for Damp-Heat Syndrome in Traditional Chinese Medicine (TCM); 3) Provide signed informed consent. (2) Inclusion Criteria for Diabetic Patients without Damp-Heat Syndrome 1) Age range from 18 to 75 years old, regardless of gender; 2) Meet the diagnostic criteria for T2DM and the diagnostic criteria for non-Damp-Heat Syndrome in TCM; 3) Provide signed informed consent. (3) Inclusion Criteria for Non-Diabetic Individuals with Damp-Heat Syndrome 1) Age range from 18 to 75 years old, regardless of gender; 2) Meet the diagnostic criteria for Damp-Heat Syndrome in TCM; 3) Meet at least one of the diagnostic criteria for obesity or hyperlipidemia; 4) Subjects without risk factors for Type 2 Diabetes Mellitus, with fasting blood glucose levels < 6.1 mmol/L and glycated hemoglobin (HbA1c) < 5.7% (indicating normal glucose metabolism); 5) Provide signed informed consent. (4) Inclusion Criteria for Normal Control Group 1) Age range from 18 to 75 years old, regardless of gender; 2) Meet the diagnostic criteria for the normal control group; 3) Provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with primary diseases of heart, liver, kidney, endocrine system or acute and chronic gastrointestinal diseases; 2. Patients with mental illness; 3. Pregnant or lactating patients; 4. Taking drugs that may affect intestinal flora in recent 2 months, such as antibiotics, berberine, defecation drugs, bifidobacteria, etc; 5. Those who had received external enema therapy within 1 month before sampling.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tongue microcirculation image;fecal sample amplicon;oral metagenome;Stool sample flora detection;oral sample amplicon;Traditional Chinese Medicine information;metabolomics of fecal samples;Metabolomics of blood samples;Detection of water molecules in urine samples;metabolomics of oral samples;Metabolomics of urine samples;glycosylated hemoglobin;Single cell sequencing of blood samples;blood glucose;Tongue color photo examination;Urine sample proteomics;proteomics of oral samples;Western blot verification of blood samples;Fundus color photograph examination;Detection of inflammatory factors and cytokines in blood samples;fecal sample metagenome;Blood sample proteomics;Detection of water molecules in blood samples;proteomics of fecal samples;Blood biochemistry; | — |
Secondary
| Measure | Time frame |
|---|---|
| routine blood test;Waist-to-Hip Ratio (WHR);Urinary creatinine;Past medical history;Stool routine;Age;Gender;urinalysis;electrocardiogram;Body Mass Index (BMI);Urinary microalbumin; | — |
Countries
China
Contacts
Public ContactLiu hongfang
Dongzhimen Hospital, Beijing University of Chinese Medicine
Outcome results
None listed