Alzheimer's disease-associated mild cognitive impairment (MCI)
Conditions
Interventions
Shenghui granule modified prescription group:One package of Shenghui granule modified Decoction once, twice a day for 9 months
placebo group:Placebo plus health education
Sponsors
Hubei Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria of AD induced MCI (2) age 50-85 years old (3) no gender limitation (4) Clinical dementia rating scale was 0.5 (5) Normal overall cognitive function: MMSE was within the normal range (6) Activities of daily living were basically normal (7) The AVLT-H recall delay scale score was less than or equal to the lower limit of the range of the corresponding age group (8) Informed consent was signed
Exclusion criteria
Exclusion criteria: (1) complicated with serious diseases of the heart, brain, liver, kidney and hematopoietic system (2) history or family history of mental disorders such as depression and anxiety (3) Excluding other types of cognitive impairment, such as vascular dementia, Parkinson's disease dementia, etc. (4) unable to complete the cognitive function test (5) patients with a history of alcohol or psychotropic drug abuse (6) pregnant women (7) Other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AD conversion rate;ADAS-cog; | — |
Secondary
| Measure | Time frame |
|---|---|
| Constitution in Chinese Medicine Questionnaire;MMSE;plasma Tau protein;plasma Neurofilament light chain;plasma Aß1-42;Dementia Syndrome Element Scale;Activity of Daily Living;MoCA;plasma Aß1-40;CDR;AVLTH;NPI; | — |
Countries
China
Contacts
Public Contactling Liu
Hubei Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed