colorectal cancer
Conditions
Interventions
treatment group:Wenyang Tongxia formula
Sponsors
Xi yuan Hospital of CACMS
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) patients aged 18-80, gender not limited, (2) pathologically diagnosed with colorectal cancer with clinical stage IV, (3) those who intended to receive maintenance therapy after criteria according to NCCN or CSCO colorectal cancer guidelines, (4) those with Eastern Cooperative Oncology Group (ECOG) score of 0-2, (5) those with expected survival =3 months, (6)those with measurable lesions according to RECIST 1.1 criteria, (7)those with no severe cardiac, pulmonary, hepatic, or renal function abnormalities, (8) those with normal coagulation function, no active bleeding or thrombotic disorders, (9) those who voluntary participation in the study, signed informed consent, (10) those who expected good compliance, able to follow-up on efficacy and adverse reactions as required by the protocol.
Exclusion criteria
Exclusion criteria: (1) patients with clinical symptoms of brain metastases, (2)those with other untreated malignancies, (3)those with dMMR for immunohistochemistry or MSI-H for genetic testing, (4) those with uncontrollable hypertension, (5) those with uncontrollable clinical cardiac symptoms or disease, (6) those with multiple factors that affect the absorption of oral medications, such as inability to swallow and intestinal obstruction (7)those at risk of bleeding, including the following: a. active peptic ulcer lesions; b. history of black stools and vomiting of blood within 3 months; c. hemoptysis within 1 month before study entry; (8) those who have major surgery, open biopsy, or significant trauma within 28 days before enrollment, (9) those who will be, or are, participating in other clinical trials (10) those who with other conditions such as pregnancy that researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maintenance progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| disease control rate; | — |
Countries
China
Contacts
Public ContactZhang Tong
Xi yuan Hospital of CACMS
Outcome results
None listed