sepsis-related acute respiratory distress syndrome
Conditions
Interventions
Control group:Warm boiled water 100ml + conventional treatment
Experimental group :QFHYTFF100ml + conventional treatment
Sponsors
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Those who meet the diagnostic criteria for sepsis and ARDS and the TCM syndrome differentiation criteria of blood stasis and heat congesting the lungs and viscera-qi obstruction. 2. Aged between 18 and 80 years old, regardless of gender. 3. Acute onset, duration of disease within 2 days. 4. Give informed consent and volunteer to be tested. The process of obtaining informed consent should comply with GCP regulations.
Exclusion criteria
Exclusion criteria: 1. Already participated in other clinical trials. 2. Pregnancy or lactation. 3. Cancer patients with disseminated tumors or receiving chemotherapy and other special treatments. 4. Severe liver function abnormalities (TBIL = 171 µmmol/L or daily increase = 17.1 µmmol/L). 5. Severe renal dysfunction (Scr increases by more than 26.5 µmmol/L or 1.5 times the baseline value within 48 hours, or urine output is <0.5 ml/kg/h, lasting for more than 6 hours). 6. Unstable angina/acute myocardial infarction, heart rate <50 beats/min, second degree or above conduction block; 7. Use of 2 vasoactive drugs within 2 hours before the start of the study and the systolic blood pressure is still <90mmHg. 8. For gastrointestinal dysfunction, traditional Chinese medicine cannot be administered through the gastrointestinal tract. 9. Those who are allergic to Chinese medicine or intolerant to Chinese medicine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilator-related parameters (tidal volume, respiratory rate, positive end-expiratory pressure, peak airway pressure, plateau pressure, driving pressure);ß-catenin\GSK3ß;E-cadherin; | — |
Countries
China
Contacts
Public Contactchenglu
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed