migraine
Conditions
Interventions
Acupuncture group:napex acupoint catgut embedding therapy
Western medicine group:metoprolol tartrate tablet
Healthy control group:None
Acupuncture and medicine group:napex acupoint catgut embedding therapy combined with metoprolol tartrate tablet
Sponsors
Nanjing Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients who met the diagnostic criteria for migraine without aura and had intermittent episodes at the time of initial treatment in this study; 2) In the range of 18 to 65 years, the course of disease is more than 6 months, the average headache attack is more than 2 times per month; 3) Did not receive preventive treatment of migraine including acupuncture and medicine in the past 1 month; 4) The patient voluntarily received the relevant preventive treatment and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Contraindications to the use of metoprolol, including but not limited to patients with symptomatic bradycardia or hypotension, atrioventricular block, morbid sinus syndrome, heart failure, acute myocardial infarction, cardiogenic shock, severe peripheral vascular disease with gangrene, treated with ß agonists, and allergic to any component or other metoprolol of ß blockers; 2) Organic lesions such as tumors, inflammation, and degenerative diseases; 3) Combined with severe neurological, cardiovascular, digestive, urinary, blood system, endocrine system diseases unrelated to migraine; 4) Pregnant and lactating women; 5) Serious mental illness, cognitive impairment so that the normal communication and diagnosis and treatment; 6) Have contraindications to MRI examination such as metal implants in the body and claustrophobia; 7) Have severe asymmetric head anatomical structure or clear lesions found in MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the number of headache attack days;frequency of headache attacks; | — |
Secondary
| Measure | Time frame |
|---|---|
| headache severity;The Migraine-specific Quality of Life Questionnaire;Amplitude of Low Frequency Fluctuation,ALFF;improved response rate by 50%; | — |
Countries
China
Contacts
Public ContactLamei Tao
Nanjing Hospital of Traditional Chinese Medicine
Outcome results
None listed